| Name | caspases (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18534571 | Mikami M, Goubaeva F, Song JH, Lee HT, Yang J: beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. Eur J Pharmacol. 2008 Jul 28;589(1-3):14-21. Epub 2008 Apr 25. We studied the effects of three beta-adrenoceptor blockers (1-(isoproplyamino)-3-(naphthalene-1-yloxy) propan-2-ol), (2-[4-[2-hydroxy-3-(1-methylethylamino) propoxyl] phenyl] ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-iden-4-yl) oxy]-3-[(1-methylethyl) amino]-2-but anol), against staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells. and ICI 118551 directly inhibited the enzymatic activity of recombinant caspase 9 while did not; however, none of the beta-adrenoceptor blockers that were examined directly blocked caspases 2 or 3 activity. |
1(0,0,0,1) | Details |
| 16699520 | Kokel D, Li Y, Qin J, Xue D: The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat Chem Biol. 2006 Jun;2(6):338-45. Epub 2006 May 14. In addition, we find that a naphthalene metabolite directly inactivates caspases by oxidizing the active site residue; this suggests a molecular mechanism by which these chemicals suppress apoptosis. |
81(1,1,1,1) | Details |
| 18782624 | Otsu K, Sato K, Sato M, Ono H, Ohba Y, Katagata Y: Impaired activation of caspase cascade during cell death induced by newly synthesized singlet generator, 1-buthylnaphthalene-4- endoperoxide. Cell Biol Int. 2008 Nov;32(11):1380-7. Epub 2008 Aug 20. Endoperoxides of naphthalene derivatives generate singlet under physiological conditions. Caspase activity in a soluble protein fraction were inhibited similarly by the above three endoperoxides. |
2(0,0,0,2) | Details |
| 18922933 | Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S: Activation of apoptosis by 1--5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res. 2008 Oct 15;68(20):8573-81. We have identified a natural compound that activates apoptosis of epithelial cancer cells through activation of tumor necrosis factor-alpha (TNF-alpha), TNF receptor (TNFR)-associated death domain (TRADD), and caspases. |
1(0,0,0,1) | Details |
| 19954251 | Tumiatti V, Milelli A, Minarini A, Micco M, Gasperi Campani A, Roncuzzi L, Baiocchi D, Marinello J, Capranico G, Zini M, Stefanelli C, Melchiorre C: Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent. J Med Chem. 2009 Dec 10;52(23):7873-7. |
0(0,0,0,0) | Details |