| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18583119 | Kulkarni-Almeida A, Suthar A, Goswami H, Vishwakarma R, Chauhan VS, Balakrishnan A, Sharma S: Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6--5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes. Phytomedicine. 2008 Dec;15(12):1079-86. Epub 2008 Jun 25. Bioassay guided fractionation identified two compounds 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6--5,7-dimethoxy-naphthalene-2-carbaldehyde with an IC (50) of 2.4 and 2.0 microM for IL-6 inhibition and an IC (50) of 15.6 and 7.0 microM for tumor necrosis factor-alpha (TNF-alpha) inhibition in THP-1 cells. |
81(1,1,1,1) | Details |
| 18922933 | Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S: Activation of apoptosis by 1--5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res. 2008 Oct 15;68(20):8573-81. We have identified a natural compound that activates apoptosis of epithelial cancer cells through activation of tumor necrosis factor-alpha (TNF-alpha), TNF receptor (TNFR)-associated death domain (TRADD), and caspases. |
1(0,0,0,1) | Details |
| 19473973 | Mancek-Keber M, Gradisar H, Inigo Pestana M, Martinez de Tejada G, Jerala R: Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem. 2009 Jul 17;284(29):19493-500. Epub 2009 May 27. Fluorescent compounds 2-(4'-(iodoacetamido) anilino) naphthalene-6- and N-pyrene maleimide formed a covalent bond with MD-2 through Cys (133) and inhibited LPS signaling. Oral intake of JTT-705 significantly inhibited endotoxin-triggered tumor necrosis factor alpha production in mice. |
1(0,0,0,1) | Details |