| 20060623 |
Czopek A, Byrtus H, Kolaczkowski M, Pawlowski M, Dybala M, Nowak G, Tatarczynska E, Wesolowska A, Chojnacka-Wojcik E: Synthesis and pharmacological evaluation of new 5-(cyclo) alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Eur J Med Chem. 2010 Apr;45(4):1295-303. Epub 2009 Dec 6.
The most interesting compound 22 (1-[3-(4-(2-methoxyphenyl) piperazin-1-yl) propyl]-3',4'-dihydro-2'H-spiro [i midazolidine-4,1'-naphthalene]-2,5-dione), a pre- and postsynaptic 5-HT (1A) receptor agonist produced an antidepressant-like effect, which was more pronounced than that of imipramine in the forced swim test in mice, without affecting locomotor activity. |
65(0,2,2,5) |
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| 19217900 |
Tadori Y, Forbes RA, McQuade RD, Kikuchi T: Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40. Epub 2009 Feb 13.
In an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of dopamine D (2) receptor reserves, we compared the properties of aripiprazole to other antipsychotics, quetiapine, clozapine, olanzapine, ziprasidone, risperidone and haloperidol, a dopamine D (2) receptor partial agonist, bifeprunox, dopamine D (3) receptor modulators, BP897 (N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl] butyl] naphthalene-2-carboxamide) and GR103691 (4'-Acetyl-N-[4-[4-(2-methoxyphenyl) piperazin-1-yl] butyl] biphenyl-4-carbox amide), and a 5-HT (1A) partial agonist, buspirone using forskolin-stimulated cAMP accumulation in clonal Chinese hamster ovary cell lines expressing low and high densities of human dopamine D (2S) receptors (hD (2S)-Low and hD (2S)-High, respectively). |
31(0,1,1,1) |
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