Protein Information

Name CD45
Synonyms B220; CD45; CD45 antigen; CD45 transcript variant; GP180; L CA; LCA; LY5…

Compound Information

Name naphthalene
CAS naphthalene

Reference List

PubMed Abstract RScore(About this table)
19861952 Krause A, Xu Y, Joh J, Hubner R, Gess A, Ilic T, Worgall S: Overexpression of sonic Hedgehog in the lung mimics the effect of lung injury and compensatory lung growth on pulmonary Sca-1 and CD34 positive cells. Mol Ther. 2010 Feb;18(2):404-12. Epub 2009 Oct 27.

An increase in the number of Sca-1 (+), CD34 (+) CD45 (-), Pecam (-) cells and activation of the sonic hedgehog (Shh) pathway was observed following unilateral pneumonectomy and naphthalene-induced airway injury.
84(1,1,1,4) Details
19056905 Teisanu RM, Lagasse E, Whitesides JF, Stripp BR: Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics. Stem Cells. 2009 Mar;27(3):612-22.

Bronchiolar stem cells have been functionally defined in vivo on the basis of their resistance to chemical (naphthalene) injury, their infrequent proliferation relative to other progenitor cell types, and their coexpression of the airway and alveolar secretory cell markers Clara cell secretory protein and pro-surfactant protein C, respectively.
On the basis of these data we show that the defining phenotype of the bronchiolar stem cell is CD45 (neg) CD31 (neg) CD34 (neg) Sca-l (low) AF (low).
1(0,0,0,1) Details