Protein Information

Name alpha lactalbumin
Synonyms LYZL7; Alpha lactalbumin; Alpha lactalbumin precursor; LALBA; Lactalbumin alpha; Lactose synthase B protein; Alpha lactalbumins; Alpha lactalbumin precursors…

Compound Information

Name naphthalene
CAS naphthalene

Reference List

PubMed Abstract RScore(About this table)
16741984 Singh SK, Kishore N: Elucidating the binding thermodynamics of 8-anilino-1-naphthalene sulfonic acid with the A-state of alpha-lactalbumin: an isothermal titration calorimetric investigation. Biopolymers. 2006 Oct 15;83(3):205-12.
62(0,2,2,2) Details
17786546 Thoppil AA, Kishore N: Equimolar mixture of 2,2,2-trifluoroethanol and 4-chloro-1-butanol is a stronger inducer of molten globule state: isothermal titration calorimetric and spectroscopic studies. Protein J. 2007 Oct;26(7):507-16.

A mixture of 4-chloro-1-butanol and 2,2,2-Trifluoroethanol (TFE) has been used to generate Molten globule (MG) state of structurally homologous but functionally different proteins bovine alpha-lactalbumin and hen egg-white lysozyme.
By intrinsic tryptophan fluorescence, acrylamide and potassium iodide quenching, 8-anilino-naphthalene sulfonic acid (ANS) binding and energy transfer studies the presence of molten globule state was confirmed.
2(0,0,0,2) Details
16878982 Greene LH, Wijesinha-Bettoni R, Redfield C: Characterization of the molten globule of human serum retinol-binding protein using NMR spectroscopy. Biochemistry. 2006 Aug 8;45(31):9475-84.

The transition at the level of individual residues is significantly more cooperative than that found previously for the archetypal molten globule, alpha-lactalbumin (alpha-LA); this difference may be due to a predominantly beta-sheet structure present in RBP in contrast to the alpha-helical nature of the alpha-LA molten globule.
Using stopped-flow fluorescence spectroscopy in the presence of 8-anilino-1-naphthalene sulfonic acid (ANS), we show that RBP populates a state with molten-globule-like characteristics early in refolding.
1(0,0,0,1) Details