Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name naphthalene
CAS naphthalene

Reference List

PubMed Abstract RScore(About this table)
18291356 Waidyanatha S, Rappaport SM: Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster mice. Chem Biol Interact. 2008 Mar 27;172(2):105-14. Epub 2008 Jan 16.

We measured cysteinyl adducts of the above metabolites in hemoglobin (Hb) and albumin (Alb) from the blood of male Swiss Webster mice dosed with 1.56-200mg naphthalene/kg b.w.
37(0,1,2,2) Details
19398502 Rowland A, Knights KM, Mackenzie PI, Miners JO: Characterization of the binding of drugs to human intestinal fatty acid binding protein (IFABP): potential role of IFABP as an alternative to albumin for in vitro-in vivo extrapolation of drug kinetic parameters. Drug Metab Dispos. 2009 Jul;37(7):1395-403. Epub 2009 Apr 27.

Each molecule of purified IFABP bound a single molecule of the fluorescent probe 1-anilino-8-naphthalene sulfonate or arachidonic acid with K (d) values similar to those reported for rat IFABP.
2(0,0,0,2) Details
18097738 Togashi DM, Ryder AG: A fluorescence analysis of ANS bound to bovine serum albumin: binding properties revisited by using energy transfer. J Fluoresc. 2008 Mar;18(2):519-26. Epub 2007 Dec 21.

In this work, the interaction between bovine serum albumin (BSA) and 1-anilino-8-naphthalene sulphonate (ANS) is revisited.
This approach, that uses both tryptophans independently from each other, is presented as a tool to help understand the binding mechanism of the albumin fluorescent complex.
1(0,0,0,1) Details
16420470 Mahesha HG, Singh SA, Srinivasan N, Rao AG: A spectroscopic study of the interaction of isoflavones with human serum albumin. FEBS J. 2006 Feb;273(3):451-67.

The ability of HSA to bind genistein is found to be lost when the tryptophan residue of albumin is modified with N-bromosuccinimide.
Temperature and ionic strength dependence and competitive binding measurements of genistein with HSA in the presence of fatty acids and 8-anilino-1-naphthalene sulfonic acid have suggested the involvement of both hydrophobic and ionic interactions in the genistein-HSA binding.
1(0,0,0,1) Details
19505452 Lin PH, Chen DR, Wang TW, Lin CH, Chuang MC: Investigation of the cumulative tissue doses of naphthoquinones in human serum using protein adducts as biomarker of exposure. Chem Biol Interact. 2009 Sep 14;181(1):107-14. Epub 2009 Jun 6.

Both 1,2-naphthoquinone (1,2-NPQ) and 1,4-naphthoquinone (1,4-NPQ) are reactive metabolites of naphthalene that are thought to be responsible for the naphthalene-induced cytotoxicity and genotoxicity.
The aim of this study was to investigate the cumulative tissue dose of 1,2-NPQ and 1,4-NPQ in human serum derived from blood donors in Taiwan via measurements of albumin adducts by a methodology, which employs trifluoroacetic acid anhydride and methanesulfonic acid to selectively cleave cysteinyl adducts on proteins.
1(0,0,0,1) Details
18710217 Tinoco AD, Eames EV, Incarvito CD, Valentine AM: Hydrolytic metal with a hydrophobic periphery: titanium (IV) complexes of naphthalene-2,3-diolate and interactions with serum albumin. Inorg Chem. 2008 Sep 15;47(18):8380-90. Epub 2008 Aug 19.

This investigation provides insight into the use of ligands to direct metal binding at different sites of albumin, which may facilitate transport to distinct targets.
1(0,0,0,1) Details