| Name | CYP2F |
|---|---|
| Synonyms | C2F1; CYP2F; CYP2F1; CYPIIF 1; CYPIIF1; Cytochrome P450 2F1; Cytochrome P450 2F1s |
| Name | naphthalene |
|---|---|
| CAS | naphthalene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17962375 | Kartha JS, Yost GS: Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes. Drug Metab Dispos. 2008 Jan;36(1):155-62. Epub 2007 Oct 25. In conclusion, this study presents evidence that 3MI is a mechanism-based inhibitor of both CYP2F3 and CYP2F1, which are important enzymes in the bioactivation of pneumotoxicants such as 3MI or 1,1-dichloroethylene or carcinogens such as naphthalene, and styrene. |
35(0,1,1,5) | Details |
| 19589367 | Cruzan G, Bus J, Banton M, Gingell R, Carlson G: Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. Regul Toxicol Pharmacol. 2009 Nov;55(2):205-18. Epub 2009 Jul 7. It is proposed that metabolism of several structurally-related chemicals by CYP2F isoforms of the cytochromes P450 family results in a cytotoxicity-driven mode of action in organs high in CYP2F; namely, CYP2F2 in nasal and lung tissue in mice and CYP2F4 in nasal tissues in rats. For naphthalene, and styrene, inhibition of toxicity with inhibition of CYP2F2 has been demonstrated. |
2(0,0,0,2) | Details |
| 16876762 | Genter MB, Marlowe J, Kevin Kerzee J, Dragin N, Puga A, Dalton TP, Nebert DW: Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochem Biophys Res Commun. 2006 Sep 15;348(1):120-3. Epub 2006 Jul 14. Whereas CYP2F enzymes are widely regarded as responsible for NP bioactivation, other metabolic enzymes--including CYP1A1 and CYP1A2--produce NP-1,2-oxide in vitro. |
2(0,0,0,2) | Details |