| 6209003 |
Gonias SL, Oakley AC, Walther PJ, Pizzo SV: Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum (II). Cancer Res. 1984 Dec;44(12 Pt 1):5764-70.
Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine, N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine, L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum (II)-protein binding in the in vitro model system. alpha 2-Macroglobulin lost 90% of its activity and was completely cross-linked, as determined with polyacrylamide gel electrophoresis, after reaction with cisplatin (0.6 to 1.0 mM). |
37(0,1,1,7) |
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