| Name | retinoid X receptor (protein family or complex) |
|---|---|
| Synonyms | Retinoid X receptor; Retinoid X receptors; RXR; RXRs |
| Name | methoxyfenozide |
|---|---|
| CAS | 3-methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16412090 | Tavva VS, Dinkins RD, Palli SR, Collins GB: Development of a methoxyfenozide-responsive gene switch for applications in plants. Plant J. 2006 Feb;45(3):457-69. We have developed a Choristoneura fumiferana ecdysone receptor (CfEcR)-based two-hybrid gene switch that works through the formation of a functional heterodimer between EcR and the retinoid X receptor (RXR) upon application of the chemical ligand methoxyfenozide. |
81(1,1,1,1) | Details |
| 17139530 | Tavva VS, Dinkins RD, Palli SR, Collins GB: Development of a tightly regulated and highly inducible ecdysone receptor gene switch for plants through the use of retinoid X receptor chimeras. Transgenic Res. 2007 Oct;16(5):599-612. Epub 2006 Dec 1. The RXR chimera 9 (CH9) along with CfEcR, in a two-hybrid format gave the best results in terms of low-background expression levels in the absence of ligand and high-induced expression levels of the reporter gene in the presence of nanomolar concentrations of the methoxyfenozide ligand. |
2(0,0,0,2) | Details |
| 17570490 | Tavva VS, Palli SR, Dinkins RD, Collins GB: Applications of EcR gene switch technology in functional genomics. Arch Insect Biochem Physiol. 2007 Jul;65(3):164-79. The ecdysone receptor gene switch is one of the best inducible gene regulation systems available, because the chemical, methoxyfenozide, required for its regulation is registered for field use. In a two-hybrid switch format, the GAL4 DNA binding domain (GAL4 DBD) was fused to the ligand binding domain (LBD) of the Choristoneura fumiferana ecdysone receptor (CfEcR); and, the VP16 activation domain (VP16 AD) was fused to the LBD of Locust migratoria retinoid X receptor (LmRXR). |
1(0,0,0,1) | Details |
| 19490110 | Beatty JM, Smagghe G, Ogura T, Nakagawa Y, Spindler-Barth M, Henrich VC: Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system--a basis for screening novel insecticidal candidates. FEBS J. 2009 Jun;276(11):3087-98. Epub 2009 Apr 22. The classic ecdysteroid receptor is a protein heterodimer composed of two nuclear receptors, the ecdysone receptor (EcR) and Ultraspiracle (USP), the insect ortholog of retinoid X receptor. The additional presence of juvenile hormone III potentiated the inductive activity of muristerone A in the receptors from both species, but juvenile hormone III was unable to potentiate the inductive activity of the diacylhydrazine methoxyfenozide (RH2485) in the receptor of either species. |
1(0,0,0,1) | Details |