Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name flumethrin
CAS cyano(4-fluoro-3-phenoxyphenyl)methyl 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
19565267 Rosario-Cruz R, Guerrero FD, Miller RJ, Rodriguez-Vivas RI, Tijerina M, Dominguez-Garcia DI, Hernandez-Ortiz R, Cornel AJ, McAbee RD, Alonso-Diaz MA: Molecular survey of pyrethroid resistance mechanisms in Mexican field populations of Rhipicephalus (Boophilus) microplus. Parasitol Res. 2009 Oct;105(4):1145-53. Epub 2009 Jun 30.

Larval packet test (LPT), knock-down (kdr) PCR allele-specific assay (PASA) and esterase activity assays were conducted in tick populations for cypermethrin, flumethrin and deltamethrin.
However a significant correlation (p < 0.01) was found between the presence of the sodium channel mutation, and resistance to SP s as measured by PASA and LPT respectively.
2(0,0,0,2) Details
16465743 Rosario-Cruz R, Guerrero FD, Miller RJ, Rodriguez-Vivas RI, Dominguez-Garcia DI, Cornel AJ, Hernandez-Ortiz R, George JE: Roles played by esterase activity and by a sodium channel mutation involved in pyrethroid resistance in populations of Boophilus microplus (Acari: Ixodidae) collected from Yucatan, Mexico. J Med Entomol. 2005 Nov;42(6):1020-5.

It was concluded that within the B. microplus populations studied, resistance to flumethrin, deltamethrin, or cypermethrin was because of the novel sodium channel mutation (Phe--> Ile amino acid substitution in the S6 transmembrane segment of domain III), and there was a correlation between tick mortality by pyrethroid exposure (larval survival) and the presence of R allele.
8(0,0,1,3) Details
18528710 Aguilar-Tipacamu G, Miller RJ, Hernandez-Ortiz R, Rodriguez-Vivas RI, Vasquez-Pelaez C, Garcia-Vazquez Z, Olvera-Valencia F, Rosario-Cruz R: Inheritance of pyrethroid resistance and a sodium channel gene mutation in the cattle tick Boophilus microplus. Parasitol Res. 2008 Aug;103(3):633-9. Epub 2008 Jun 5.

The reciprocal crosses show a predominance of the heterozygote genotype, in agreement with the significant decrease of the acaricide resistance to cypermethrin, deltamethrin, and flumethrin.
3(0,0,0,3) Details