Protein Information

Name neurotrophin
Synonyms Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20056136 Formaggio E, Fazzini F, Dalfini AC, Di Chio M, Cantu C, Decimo I, Fiorini Z, Fumagalli G, Chiamulera C: Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.
62(0,2,2,2) Details
19824047 Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G: Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr Pulmonol. 2009 Nov;44(11):1075-84.

Expression of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor, of their high-affinity tyrosine kinase receptors (trkA and trkB, respectively), and of the low-affinity receptor p75 (NTR) was measured in the lungs of nicotine-exposed rats both at the mRNA level by reverse-transcription polymerase chain reaction and at the protein level by enzyme-linked immunoassay.
38(0,1,2,3) Details
19492919 Andresen JH, Loberg EM, Wright M, Goverud IL, Stray-Pedersen B, Saugstad OD: Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets. J Perinat Med. 2009;37(5):553-60.
31(0,0,5,6) Details
19224602 Correll JA, Noel DM, Sheppard AB, Thompson KN, Li Y, Yin D, Brown RW: Nicotine sensitization and analysis of brain-derived neurotrophic factor in adolescent beta-arrestin-2 knockout mice. Synapse. 2009 Jun;63(6):510-9.
30(0,0,5,5) Details
20081236 Czubak A, Nowakowska E, Kus K, Burda K, Metelska J, Baer-Dubowska W, Cichocki M: Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF). Pharmacol Rep. 2009 Nov-Dec;61(6):1017-23.
18(0,0,2,8) Details
19850105 Bhang SY, Choi SW, Ahn JH: Changes in plasma brain-derived neurotrophic factor levels in smokers after smoking cessation. Neurosci Lett. 2010 Jan 1;468(1):7-11. Epub 2009 Oct 20.

Of the 45 smokers, 12 were taking varenicline, 21 were using a nicotine patch, and 12 were unaided in their cessation effort by their own choice.
8(0,0,0,8) Details
19410565 Son JH, Winzer-Serhan UH: Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res. 2009 Jun 30;1278:1-14. Epub 2009 May 3.

Therefore, we determined whether chronic neonatal nicotine (CNN) exposure increased mRNA expression levels of brain-derived neurotrophic factor (BDNF), nerve-growth factor (NGF), neurotrophin-3 (NT-3), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor-1 (IGF-1).
7(0,0,1,2) Details
19464074 Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA: Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. Neurobiol Aging. 2009 May 20.

These effects of nicotine may be due, at least in part, to upregulation of brain derived neurotropic factor (BDNF).
6(0,0,1,1) Details
19890259 Wang J, Li MD: Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. Neuropsychopharmacology. 2010 Feb;35(3):702-19. Epub 2009 Nov 4.


Further, we found that serotonin receptor signaling and tryptophan metabolism pathways were shared by SI/P and ND, tight junction signaling pathway was shared by SI/P and SC, and gap junction, neurotrophin/TRK signaling, synaptic long-term potentiation, and tyrosine metabolism were shared between ND and SC.
1(0,0,0,1) Details
19830406 El-Ghundi MB, Fan T, Karasinska JM, Yeung J, Zhou M, O'Dowd BF, George SR: Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice. Psychopharmacology. 2010 Jan;207(4):599-618. Epub 2009 Oct 15.

METHODS: D (1) (-/-) and wild-type (D (1) (+/+) ) mice pretreated with amphetamine (1 mg/kg, 3-7 days) or various doses of nicotine (chronically but intermittently) were challenged with amphetamine (0.7 and/or 1 mg/kg) after short and long abstinence periods.
Expression of brain-derived neurotrophic factor (BDNF) and phosphorylated c-AMP response element binding protein (p-CREB) genes were measured under basal conditions and after acute or repeated amphetamine treatments.
1(0,0,0,1) Details