Protein Information

Name NR1
Synonyms GRIN 1; NR1; GRIN1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta 1 precursor; N methyl D aspartate receptor subunit NR1; NMDA receptor 1; NMDA 1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20188799 Kovacs K, Lajtha A, Sershen H: Effect of nicotine and cocaine on neurofilaments and receptors in whole brain tissue and synaptoneurosome preparations. Brain Res Bull. 2010 Feb 25.

The present study examined the effect of repeated nicotine and cocaine administration on the expression of neurofilament proteins (NF-L, -M, and -H), actin, and on alpha-7 nicotinic, dopamine D1 and NMDA NR1 receptors in brain.
32(0,1,1,2) Details
20062537 Wang LP, Li F, Shen X, Tsien JZ: Conditional knockout of NMDA receptors in dopamine neurons prevents nicotine-conditioned place preference. PLoS One. 2010 Jan 7;5(1):e8616.

By generating dopamine neuron-specific NR1 knockout mice using cre/loxP-mediated method, we demonstrate that genetic inactivation of the NMDA receptors in ventral tegmental area dopamine neurons selectively prevents nicotine-conditioned place preference.
31(0,1,1,1) Details