| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20223227 | Landgraf D, Barth M, Layer PG, Sperling LE: as a possible signaling molecule in embryonic stem cells: Studies on survival, proliferation and death. Chem Biol Interact. 2010 Mar 9. It is noteworthy that murine and human embryonic stem cells also synthesize and express the enzyme acetylcholinesterase and muscarinic receptors. and nicotine, but not muscarine could induce the mobilization of the intracellular Ca (2+). |
1(0,0,0,1) | Details |
| 19077124 | Welsby PJ, Rowan MJ, Anwyl R: Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. Eur J Neurosci. 2009 Jan;29(1):65-75. Epub 2008 Dec 11. In particular, the involvement of activation of intracellular kinases was examined using selective kinase antagonists, and the effects of enhancing cholinergic function with positive allosteric modulators of the alpha7 nAChR and with acetylcholinesterase (AChE) inhibitors were also investigated. Chronic nicotine enhancement of LTP was found to be dependent on PKA, ERK and Src kinases. |
1(0,0,0,1) | Details |
| 19526284 | Das JR, Tizabi Y: Additive protective effects of and nicotine against -induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204. Epub 2009 Mar 20. is a reversible non-competitive acetylcholinesterase inhibitor that is approved for use in mild to moderate Alzheimer's disease. |
1(0,0,0,1) | Details |
| 20060019 | Abreu-Villaca Y, Filgueiras CC, Manhaes AC: Developmental aspects of the cholinergic system. Behav Brain Res. 2010 Jan 6. In the current review, we focus on the developmental aspects associated with major components of the cholinergic system: choline acetyltransferase, vesicular acetylcholine transporter, high-affinity choline transporter, acetylcholinesterase, nicotinic and muscarinic receptors. It will be noticed that evidence regarding the developmental aspects of the cholinergic system comes mostly from studies that used agonists, such as nicotine, and antagonists, such as hemicholinium-3. |
1(0,0,0,1) | Details |
| 20047798 | Wang QY, Cai C, Duan YZ, Wang XJ: Nicotinic acetylcholine receptor but not acetylcholinesterase plays an important role in nicotine-related periodontitis. Med Hypotheses. 2010 Jan 2. |
0(0,0,0,0) | Details |
| 20097188 | Lee S, Poet TS, Smith JN, Busby-Hjerpe AL, Timchalk C: Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats. Chem Biol Interact. 2010 Mar 30;184(3):449-57. Epub 2010 Jan 25. The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. |
163(2,2,2,3) | Details |
| 19714494 | Akaike A, Takada-Takatori Y, Kume T, Izumi Y: Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci. 2010 Jan;40(1-2):211-6. |
126(0,4,4,6) | Details |
| 19625132 | Wang Y, Ge X, Xu XF, Wang XJ: Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Med Hypotheses. 2009 Oct;73(4):604-5. Epub 2009 Jul 21. |
65(0,2,2,5) | Details |
| 20217330 | Brundage CM, Nelson CA, Taylor BE: Cholinergic Sensitivity of the Developing Bullfrog (Rana catesbeiana) does not Explain Vulnerability to Chronic Nicotine Exposure. Adv Exp Med Biol. 2010;669:103-7. Acute bath application of 1 muM galantamine, an acetylcholinesterase inhibitor, significantly attenuated both bullfrog normocapnic neuroventilation and response to hypercapnia in a fashion similar to that of acute nicotine. |
31(0,1,1,1) | Details |
| 20132903 | de Bruin NM, Prickaerts J, Lange JH, Akkerman S, Andriambeloson E, de Haan M, Wijnen J, van Drimmelen M, Hissink E, Heijink L, Kruse CG: SLV330, a cannabinoid CB (1) receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents. Neurobiol Learn Mem. 2010 Feb 2. The acetylcholinesterase inhibitor (AChEI) (R), approved for symptomatic treatment of Alzheimer's disease) and nicotine were used as reference compounds. |
31(0,1,1,1) | Details |
| 20309727 | Jamal M, Ameno K, Miki T, Tanaka N, Ohkubo E, Kinoshita H: Effects of Systemic Nicotine, or Their Combination on Cholinergic Markers in the Frontal Cortex and Hippocampus of Rat. Neurochem Res. 2010 Mar 23. The present study extends that finding by examining the effects of nicotine (Nic), Alc, and their combination on ChAT and acetylcholinesterase (AChE) in the frontal cortex and hippocampus of rat. |
8(0,0,1,3) | Details |
| 19077054 | Noh MY, Koh SH, Kim Y, Kim HY, Cho GW, Kim SH: Neuroprotective effects of through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. Epub 2009 Jan 23. Acetylcholinesterase inhibitors (AChE-inhibitors) are used for the treatment of Alzheimer's disease. |
6(0,0,0,6) | Details |
| 19962381 | Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T: an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. J Mol Cell Cardiol. 2010 Apr;48(4):680-93. Epub 2009 Dec 3. and nicotine upregulated signal transduction with acceleration of tube formation, suggesting that promotes a common angiogenesis pathway. |
2(0,0,0,2) | Details |
| 20211194 | Gustafsson H, Runesson J, Lundqvist J, Lindegren H, Axelsson V, Forsby A: Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicol Appl Pharmacol. 2010 Mar 6. We studied cell membrane potential (CMP), (NA) uptake, acetylcholine esterase (AChE) activity, acetylcholine receptor (AChR) signalling and voltage-operated calcium channel (VOCC) function in human neuroblastoma SH-SY5Y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. The CMP assay was the most sensitive assay, identifying eight chemicals as alerts and improving the LC50 correlation for nicotine, lindane, atropine and methadone. |
2(0,0,0,2) | Details |