Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name diafenthiuron
CAS

Reference List

PubMed Abstract RScore(About this table)
1832178 Kadir HA, Knowles CO: Inhibition of ATP dephosphorylation by acaricides with emphasis on the anti-ATPase activity of the carbodiimide metabolite of diafenthiuron. J Econ Entomol. 1991 Jun;84(3):801-5.
247(3,3,3,7) Details
11695192 Kayser H, Eilinger P: Metabolism of diafenthiuron by microsomal oxidation: procide activation and inactivation as mechanisms contributing to selectivity. Pest Manag Sci. 2001 Oct;57(10):975-80.

The carbodiimide inhibits mitochondrial respiration by selective and covalent binding to the proteolipid (8 kDa) of Fo-ATPase in the inner membrane and to porin (30 kDa) in the outer membrane.
1(0,0,0,1) Details
8703976 Wiesner P, Popp B, Schmid A, Benz R, Kayser H: Isolation of mitochondrial porin of the fly Protophormia: porin modification by the pesticide CGA 140'408 studied in lipid bilayer membranes. Biochim Biophys Acta. 1996 Jul 25;1282(2):216-24.

This carbodiimide labels both a F0-component of the inner membrane ATPase and outer membrane porin in a similar way as N,N'-dicyclohexylcarbodiimide (DCCD).
Porin was also isolated and purified from mitochondria, which were treated with the carbodiimide CGA 140'408 It represents the active derivative of diafenthiuron a new acaricide and insecticide.
1(0,0,0,1) Details