Protein Information

Name homeobox
Synonyms HPX 6; HPX6; LBX 1; LBX1; LBX1H; Lady bird like homeobox; Ladybird homeobox protein homolog 1; Transcription factor LBX1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
20202168 Todd AT, Liu E, Polvi SL, Pammett RT, Page JE: A functional genomics screen identifies diverse transcription factors that regulate alkaloid biosynthesis in Nicotiana benthamiana. Plant J. 2010 Feb 26.

VIGS of a basic helix-loop-helix (bHLH) TF, NbbHLH3, and an auxin response factor TF, NbARF1, increased nicotine content compared to control plants; silencing the bHLH family members, NbbHLH1 and NbbHLH2, an ethylene response factor TF, NbERF1, and a homeobox domain-like TF, NbHB1, reduced nicotine levels.
81(1,1,1,1) Details
19721000 Chen X, Cho K, Singer BH, Zhang H: PKNOX2 gene is significantly associated with substance dependence in European-origin women. Proc Natl Acad Sci U S A. 2009 Sep 10.

Many studies have reported and implicated genes associated with various substance dependence outcomes, including addiction to nicotine and addiction to alcohol.
We identified a strong (odds ratio = 1.77) and significant (P value = 7E-8) association signal with the PBX/knotted 1 homeobox 2 (PKNOX2) gene on chromosome 11 in European-origin women with the composite phenotype.
1(0,0,0,1) Details