Protein Information

Name bradykinin
Synonyms Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19883631 Vetter I, Lewis RJ: Characterization of endogenous calcium responses in neuronal cell lines. Biochem Pharmacol. 2010 Mar 15;79(6):908-20. Epub 2009 Oct 31.

This study revealed a remarkable diversity of endogenous Ca (2+) responses in these cell lines, with one or more cell lines responding to addition of trypsin, bradykinin, ATP, nicotine, acetylcholine, histamine and neurotensin.
6(0,0,1,1) Details
20113502 Xu Y, Zhang Y, Cardell LO: Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. Respir Res. 2010 Jan 29;11:13.

Administration of phosphodiesterase inhibitors (YM976 and theophylline), glucocorticoid (dexamethasone) or adenylcyclase activator (forskolin) suppressed the nicotine-enhanced airway contractile response to des-Arg9-bradykinin and bradykinin.
32(0,1,1,2) Details