Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19443934 Biala G, Kruk M: Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze. Pharmacol Rep. 2009 Mar-Apr;61(2):236-44.
38(0,1,2,3) Details
20195113 Rinker B, Fink BF, Barry NG, Fife JA, Milan ME: The effect of calcium channel blockers on smoking-induced skin flap necrosis. Plast Reconstr Surg. 2010 Mar;125(3):866-71.

BACKGROUND: Calcium channel blockers have been shown experimentally to reverse many of the effects of nicotine.
10(0,0,1,5) Details
20211194 Gustafsson H, Runesson J, Lundqvist J, Lindegren H, Axelsson V, Forsby A: Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicol Appl Pharmacol. 2010 Mar 6.

We studied cell membrane potential (CMP), noradrenalin (NA) uptake, acetylcholine esterase (AChE) activity, acetylcholine receptor (AChR) signalling and voltage-operated calcium channel (VOCC) function in human neuroblastoma SH-SY5Y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals.
The CMP assay was the most sensitive assay, identifying eight chemicals as neurotoxic alerts and improving the LC50 correlation for nicotine, lindane, atropine and methadone.
1(0,0,0,1) Details
19804796 Bruijnzeel AW: kappa-Opioid receptor signaling and brain reward function. . Brain Res Rev. 2009 Dec 11;62(1):127-46. Epub 2009 Oct 2.

This might explain that in some studies kappa-opioid receptor agonists attenuate nicotine and opioid withdrawal symptomatology.
Calcium channel inhibitors have antidepressant-like effects and inhibit the release of norepinephrine.
1(0,0,0,1) Details