| Name | serotonin transporter |
|---|---|
| Synonyms | Sodium dependent serotonin transporter; OCD1; 5 hydroxytryptamine transporter; 5HT transporter; 5HTT; HTT; OCD 1; SERT… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19372687 | Slotkin TA, Seidler FJ: Nicotine exposure in adolescence alters the response of systems to nicotine administered subsequently in adulthood. Dev Neurosci. 2009;31(1-2):58-70. Epub 2009 Apr 17. We gave nicotine to adolescent rats (postnatal days, PD, 30-47), simulating plasma levels in smokers, and then examined the subsequent effects of nicotine given again in young adulthood (PD 90-107), focusing on 5-HT (1A) and 5-HT (2) receptors and the 5-HT transporter during nicotine treatment (PD 105) and withdrawal (PD 110, 120, 130), and long-term changes (PD 180). |
81(1,1,1,1) | Details |
| 20211707 | Slotkin TA, Seidler FJ: Mimicking maternal smoking and pharmacotherapy of preterm labor: Interactions of fetal nicotine and dexamethasone on and synaptic function in adolescence and adulthood. Brain Res Bull. 2010 Mar 6. Males displayed persistent upregulation of 5HT (1A) and 5HT (2) receptors and the 5HT transporter, with a distinct hierarchy of effects: nicotine |
31(0,1,1,1) | Details |
| 19586232 | Carlson JM, Gilbert DG, Riise H, Rabinovich NE, Sugai C, Froeliger B: Serotonin transporter genotype and depressive symptoms moderate effects of nicotine on spatial working memory. Exp Clin Psychopharmacol. 2009 Jun;17(3):173-80. |
6(0,0,1,1) | Details |
| 19567154 | Chu SL, Xiao D, Wang C, Jing H: Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males. Chin Med J. 2009 Jun 20;122(12):1365-8. However, only 5% of smokers can successfully quit without therapy owing to the highly addictive properties of nicotine. |
3(0,0,0,3) | Details |
| 20102619 | McEachin RC, Saccone NL, Saccone SF, Kleyman-Smith YD, Kar T, Kare RK, Ade AS, Sartor MA, Cavalcoli JD, McInnis MG: Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. BMC Med Genet. 2010 Jan 26;11:14. We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders. Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD. |
1(0,0,0,1) | Details |
| 19413407 | Gilbert DG, Zuo Y, Rabinovich NE, Riise H, Needham R, Huggenvik JI: Neurotransmission-related genetic polymorphisms, negative affectivity traits, and gender predict tobacco abstinence symptoms across 44 days with and without nicotine patch. J Abnorm Psychol. 2009 May;118(2):322-34. |
0(0,0,0,0) | Details |
| 19452140 | Andreasen JT, Nielsen EO, Redrobe JP: Chronic oral nicotine increases brain [3H] epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test. Psychopharmacology. 2009 Aug;205(3):517-28. Epub 2009 May 12. Finally, the effects on the brain expression levels of high- and low-affinity nicotinic acetylcholine receptors (nAChRs) and the transporters for (SERT) and (NET) were assessed using [(3) H] epibatidine, [(3) H] alpha-bungarotoxin, [(3) H] and [(3) H] nisoxetine binding, respectively. |
1(0,0,0,1) | Details |
| 20060656 | Iordanidou M, Tavridou A, Petridis I, Kyroglou S, Kaklamanis L, Christakidis D, Manolopoulos VG: Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians. Drug Alcohol Depend. 2010 Apr 1;108(1-2):70-6. Epub 2010 Jan 8. BACKGROUND: The serotonergic system may be implicated in susceptibility to nicotine dependence as nicotine increases release in brain and symptoms of nicotine withdrawal may be modulated by diminished serotonergic neurotransmission. METHODS: 5-HTTLPR polymorphism of the 5-HT transporter gene and -759C/T (rs3813929) and -697G/C (rs518147) polymorphisms of the 5-HT (2C) receptor gene were analyzed in 172 smoking initiators and 254 non-initiators, using PCR-RFLP method. |
1(0,0,0,1) | Details |
| 19396697 | Nilsson KW, Oreland L, Kronstrand R, Leppert J: Smoking as a product of gene-environment interaction. . Ups J Med Sci. 2009;114(2):100-7. As one of the candidate genes in relation to smoking, the serotonin transporter gene (5-HTTLPR) has been suggested, however with conflicting results. The objective of the present study was to investigate the interaction between a variation in the 5-HTTLPR and family environment in relation to smoking habits, nicotine dependence, and nicotine and levels in hair samples. |
1(0,0,0,1) | Details |
| 19086091 | Veletza S, Samakouri M, Emmanouil G, Trypsianis G, Kourmouli N, Livaditis M: Psychological vulnerability differences in students--carriers or not of the serotonin transporter promoter allele S: effect of adverse experiences. Synapse. 2009 Mar;63(3):193-200. Students were evaluated with a battery of psychological tests (Zung depression rating scale, symptoms check-list-90-R, Eysenck personality inventory); they also answered questionnaires regarding serious past adverse experiences as well as nicotine and use. |
0(0,0,0,0) | Details |