| 19481804 |
Rodrigues KJ, Santana MB, Do Nascimento JL, Picanco-Diniz DL, Maues LA, Santos SN, Ferreira VM, Alfonso M, Duran R, Faro LR: Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats. Ecotoxicol Environ Saf. 2010 Jan;73(1):101-7. Epub 2009 May 29.
Therefore, we aimed to determine the potential effects of thiamethoxam on mammalian brain, testing the performance in the open field and elevated plus-maze of rats exposed to this insecticide and, in order to establish the neurochemical endpoints, we measured the acetylcholinesterase activity in different brain regions (hippocampus, striatum and cortex) and the high-affinity choline uptake (HACU) in synaptosomes from rat hippocampus. |
33(0,1,1,3) |
Details |