Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name crufomate
CAS 2-chloro-4-(1,1-dimethylethyl)phenyl methyl methylphosphoramidate

Reference List

PubMed Abstract RScore(About this table)
7059283 de Jong LP, Wolring GZ, Benschop HP: Reactivation of acetylcholinesterase inhibited by methamidophos and analogous (di) methylphosphoramidates. Arch Toxicol. 1982 Jan;49(2):175-83.

Upon comparison of the reactivation of AChE inhibited by methamidophos with that of AChE inhibited by an N-methyl analogue, crufomate, and an N,N-dimethyl analogue, tabun, it appears that the rate of spontaneous reactivation decreases with increasing alkylation of the P-NH2 group.
165(2,2,2,5) Details