| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | fenamiphos |
|---|---|
| CAS | ethyl 3-methyl-4-(methylthio)phenyl (1-methylethyl)phosphoramidate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19287708 | Pree DJ, Townshend JL, Cole KJ: Inhibition of Acetylcholinesterases from Aphelenchus avenae by Carbofuran and Fenamiphos. J Nematol. 1990 Apr;22(2):182-6. |
169(2,2,3,4) | Details |
| 19899158 | Wang C, Zhang N, Li L, Zhang Q, Zhao M, Liu W: Enantioselective interaction with acetylcholinesterase of an organophosphate insecticide fenamiphos. Chirality. 2009 Nov 6. |
163(2,2,2,3) | Details |
| 19732756 | Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F: Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad. Biochem Pharmacol. 2010 Feb 1;79(3):507-15. Epub 2009 Sep 2. In this article, we report the intermolecular interactions between Mus musculus acetylcholinesterase inhibited by the insecticide fenamiphos (fep-mAChE) and HI-6 or Ortho-7 revealed by a combination of crystallography and kinetics. |
113(1,2,2,3) | Details |
| 17382909 | Worek F, Aurbek N, Koller M, Becker C, Eyer P, Thiermann H: Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. Biochem Pharmacol. 2007 Jun 1;73(11):1807-17. Epub 2007 Feb 16. However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. |
88(1,1,1,8) | Details |
| 17402711 | Hornberg A, Tunemalm AK, Ekstrom F: Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state. Biochemistry. 2007 Apr 24;46(16):4815-25. Epub 2007 Apr 3. In this study, we present crystal structures of the non-aged and aged complexes between Mus musculus AChE (mAChE) and the nerve agents sarin, VX, and diisopropyl fluorophosphate (DFP) and the OP-based insecticides methamidophos (MeP) and fenamiphos (FeP). |
35(0,1,1,5) | Details |
| 19283090 | Opperman CH, Chang S: Effects of Aldicarb and Fenamiphos on Acetycholinesterase and Motility of Caenorhabditis elegans. J Nematol. 1991 Jan;23(1):20-7. The ability of Caenorhabditis elegans to recover from exposure to high doses of aldicarb and fenamiphos was examined at the organismal and biochemical levels by determination of movement and acetylcholinesterase activity. |
13(0,0,2,3) | Details |
| 19287642 | Pree DJ, Townshend JL, Archibald DE: and Organophosphorus Nematicides: Acetylcholinesterase inhibition and Effects on Dispersal. J Nematol. 1989 Oct;21(4):483-9. All pesticides tested affected nematode movement, but fenamiphos was more inhibitory than others. |
4(0,0,0,4) | Details |
| 1685431 | Noel GR, Mayasich SO: Partial characterization of soluble esterase from Heterodera glycines and inhibition by aldicarb and phenamiphos. Comp Biochem Physiol C. 1991;99(3):537-40. The data demonstrated that aldicarb and phenamiphos were active against esterases other than acetylcholinesterase. |
1(0,0,0,1) | Details |
| 3672530 | Pauluhn J, Machemer L, Kimmerle G: Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct 30;46(2):177-90. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the propoxur. |
1(0,0,0,1) | Details |
| 12417477 | Paz-y-Mino C, Bustamante G, Sanchez ME, Leone PE: Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ Health Perspect. 2002 Nov;110(11):1077-80. This study included 41 individuals occupationally exposed to 27 pesticides, some of which are restricted in many countries and are classified as extremely toxic by the World Health Organization; among these are aldicarb and fenamiphos. Levels of erythrocyte acetylcholinesterase were also determined as a complementary metabolic study. |
1(0,0,0,1) | Details |