Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name fenamiphos
CAS ethyl 3-methyl-4-(methylthio)phenyl (1-methylethyl)phosphoramidate

Reference List

PubMed Abstract RScore(About this table)
15113602 McDaniel KL, Moser VC: Differential profiles of cholinesterase inhibition and neurobehavioral effects in rats exposed to fenamiphos or profenofos. Neurotoxicol Teratol. 2004 May-Jun;26(3):407-15.
162(2,2,2,2) Details
15041257 Wang YS, Tai KT, Yen JH: Separation, bioactivity, and dissipation of enantiomers of the organophosphorus insecticide fenamiphos. Ecotoxicol Environ Saf. 2004 Mar;57(3):346-53.

However, (+)-fenamiphos proved to be about 20 times more toxic to Daphnia and only about four times more inhibitory activity to butyrylcholinesterase than (-)-fenamiphos.
144(1,3,3,4) Details
9891917 Astroff AB, Young AD: The relationship between maternal and fetal effects following maternal organophosphate exposure during gestation in the rat. Toxicol Ind Health. 1998 Nov-Dec;14(6):869-89.

This study compared the maternal and fetal effects, including cholinesterase inhibition, following gestational exposure to six organophosphates: tribufos, oxydemeton-methyl, azinphos-methyl, fenamiphos, isofenphos, and fenthion in the Sprague-Dawley rat.
116(1,2,2,6) Details
10794385 Sheets LP: A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology. 2000 Feb-Apr;21(1-2):57-63.

The first involves multi-generation reproduction studies with rats that were treated with OP insecticides (coumaphos, fenamiphos, tribufos, trichlorfon, or oxydemeton-methyl) through the diet and examined for effects, including cholinesterase (ChE) inhibition.
31(0,1,1,1) Details
3672530 Pauluhn J, Machemer L, Kimmerle G: Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct 30;46(2):177-90.

The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the carbamate propoxur.
6(0,0,0,6) Details
9875697 Astroff AB, Freshwater KJ, Eigenberg DA: Comparative organophosphate-induced effects observed in adult and neonatal Sprague-Dawley rats during the conduct of multigeneration toxicity studies. Reprod Toxicol. 1998 Nov-Dec;12(6):619-45.

Five organophosphates: tribufos, oxydemeton-methyl, fenamiphos, coumaphos, and trichlorfon were evaluated for their potential to produce reproductive and neonatal toxicity following continuous dietary exposure during multigenerational reproduction toxicity studies in the Sprague-Dawley rat.
Significant inhibition of parental cholinesterase activities (plasma, erythrocyte, and brain) was similarly observed in both generations with all test compounds, with at least the highest concentrations.
3(0,0,0,3) Details
1619216 Salama AK, Radwan MA, el-Shahawi FI: Pharmacokinetic profile and anticholinesterase properties of phenamiphos in male rats. J Environ Sci Health B. 1992 Jun;27(3):307-23.

3(0,0,0,3) Details
6510327 Hill EF, Camardese MB: Toxicity of anticholinesterase insecticides to birds: technical grade versus granular formulations. Ecotoxicol Environ Saf. 1984 Dec;8(6):551-63.

The test chemicals were Amaze 15G (isofenphos), Counter 15G (terbufos), Dasanit 15G (fensulfothion), Diazinon 14G (diazinon), Di-Syston 15G (disulfoton), Dyfonate 20G (fonofos), Furadan 10G (carbofuran), Lorsban 15G (chlorpyrifos), Nemacur 15G (fenamiphos), Parathion 10G (parathion), Tattoo 10G (bendiocarb), Temik 15G (aldicarb), and Thimet 15G (phorate).
2(0,0,0,2) Details
2815094 Mohammad FK, al-Kassim NA, Abdul-Latif AR: Effect of diphenhydramine on organophosphorus insecticide toxicity in mice. Toxicology. 1989 Sep;58(1):91-5.

Male mice were treated orally with the organophosphorus insecticides fenamiphos and dichlorvos at 10 and 150 mg/kg, respectively.
The insecticides produced signs of toxicosis characteristic of cholinesterase inhibition, and induced death in all treated mice.
1(0,0,0,1) Details