Protein Information

Name corticotropin releasing factor
Synonyms CRF; CRH; Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticoliberins; Corticoliberin precursors…

Compound Information

Name acephate
CAS

Reference List

PubMed Abstract RScore(About this table)
12039681 Singh AK: Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2002 May;132(1):9-24.
 31(0,1,1,1) Details
15697179 Singh AK, Jiang Y: Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephate. Toxicol Ind Health. 2003 Jul;19(2-6):93-108.

This study showed that LPS injection in control rats caused (1) a time-dependent increase in blood lymphocyte enumeration and differentiation, and (2) a sequential increase the pro-inflammatory (interleukin-1beta (IL1beta), tumor necrosis factor-alpha (TNFalpha), interferon-gamma (INTgamma), and inducible nitric oxide synthase (iNOS)) and anti-inflammatory (interleukin-4 (IL-4), corticotropin-releasing factor (CRF), and blood corticosterone (Cort)) cytokines.		 1(0,0,0,1) Details