| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | EPN |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6464348 | Nelson DL, Lamb DW, Mihail F: A study of liver microsomal enzymes in rats following propoxur (Baygon) administration. Vet Hum Toxicol. 1984 Aug;26(4):305-8. Microsomal enzyme activity was measured by testing the ability of liver homogenates to degrade EPN (O-ethyl O- phenylphosphonothioate) to The activity of aminopyrine-N-demethylase, cytochrome P-450 and p-nitroanisole-O-demethylase in liver homogenates of rats receiving propoxur was measured. |
1(0,0,0,1) | Details |
| 7324501 | Horie T, Ohno T, Kinoshita K, Kitagawa H, Kitada M: Studies of metabolism of tripamide, a new antihypertensive agent. Xenobiotica. 1981 Oct;11(10):693-99. Inhibition of the hydroxylation of tripamide by antibodies of cytochrome P-450 and P-448 was studied. |
1(0,0,0,1) | Details |
| 2730675 | Forsyth CS, Chambers JE: Activation and degradation of the phosphorothionate insecticides parathion and EPN by rat brain. Biochem Pharmacol. 1989 May 15;38(10):1597-603. Cytochrome P-450-dependent monooxygenases are known to activate phosphorothionate insecticides to their oxon analogs by oxidative desulfuration. |
1(0,0,0,1) | Details |
| 2019992 | Abou-Donia MB, Hu ZH, Lapadula DM, Gupta RP: Mechanisms of joint neurotoxicity of n-hexane, methyl isobutyl ketone and O-ethyl O- phenylphosphonothioate in hens. J Pharmacol Exp Ther. 1991 Apr;257(1):282-9. MiBK alone or in combination with EPN and n-hexane induced liver microsomal cytochrome P-450 content and phenobarbital-inducible cytochrome P-450 enzyme activities. |
1(0,0,0,1) | Details |
| 6778679 | Carlson GP, Smith EN, Johnson KM: Induction of xenobiotic metabolism in rat liver by chlorinated biphenyl ether isomers. Drug Chem Toxicol. 1980;3(3):293-303. Decachlorodiphenyl ether caused increases in EPN detoxification, cytochrome c reductase and cytochrome P-450 but did not alter aryl hydrocarbon hydroxylase (AHH). |
0(0,0,0,0) | Details |
| 6239051 | Sugiyama S, Satoh T, Ueno K, Igarashi T, Kitagawa H: Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats. Jpn J Pharmacol. 1984 Aug;35(4):433-7. This potentiation of EPN-induced inhibition of carboxylesterase may be, at least in part, explained by the fact that treatment of rats with 6-aminonicotinamide resulted in a significant increase in level in liver cytosol which, in turn, stimulated formation of an EPN analog, a potent inhibitor of carboxylesterase, through cytochrome P-450-coupled monooxygenase. |
81(1,1,1,1) | Details |
| 3999477 | Sugiyama S, Igarashi T, Ueno K, Satoh T, Kitagawa H: NAD-coupled enzymatic oxidation of O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) to its analog with liver microsomes of rats. Jpn J Pharmacol. 1985 Mar;37(3):245-52. This potentiation of the anti-CEase action of EPN by NAD was significantly inhibited by addition of SKF 525-A or (KSCN); and a simultaneous decrease in cytochrome P-450 contents were also observed. |
2(0,0,0,2) | Details |
| 7376196 | Carlson GP: Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol Lett. 1980 Jan;5(1):19-25. Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, -cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo [a] pyrene hydroxylase. |
2(0,0,0,2) | Details |
| 4049408 | Abou-Donia MB, Lapadula DM, Campbell G, Abdo KM: The joint action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O- phenylphosphonothioate in hens: potentiating effect. Toxicol Appl Pharmacol. 1985 Jun 15;79(1):69-82. Pretreatment with three daily ip doses of 5 mmol/kg technical grade MBK or methyl n-butyl ketone (MnBK), equally increased chicken hepatic microsomal cytochrome P-450 content. |
1(0,0,0,1) | Details |
| 1868789 | Babich H, Rosenberg DW, Borenfreund E: In vitro cytotoxicity studies with the fish hepatoma cell line, PLHC-1 (Poeciliopsis lucida). Ecotoxicol Environ Saf. 1991 Jun;21(3):327-36. Xenobiotic-metabolizing capacity was temperature dependent, with enzymatic activity increasing as the temperature was increased from 28 to 34 to 37 degrees C, was inducible by Aroclor 1254 (a chemical inducer of cytochrome P450-dependent monooxygenase activity), and was reduced by EPN (an inhibitor of P450 activity). |
1(0,0,0,1) | Details |
| 102051 | Carlson GP: Effect of trichlorophenols on xenobiotic metabolism in the rat. Toxicology. 1978 Oct;11(2):145-51. Only 2,4,5-trichlorophenol at the highest dose decreased microsomal -cytochrome c reductase activity and cytochrome P-450 content. |
1(0,0,0,1) | Details |
| 6250253 | Carlson GP: Induction of xenobiotic metabolism in rats by brominated diphenyl ethers administered for 90 days. Toxicol Lett. 1980 Aug;6(3):207-12. The administration of doses as low as 0.78 mu mol/kg/day p.o. for 90 dys of the commercial fire retardants pentabromodiphenyl ehter and octabromodiphenyl ether to rats resulted in increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification and p-nitroanisole demethylation. This dose of pentabromodiphenyl ehter and higher doses of octabromodiphenyl ether also increased cytochrome P-450 and cytochrome c reductase. |
1(0,0,0,1) | Details |