Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name EPN
CAS

Reference List

PubMed Abstract RScore(About this table)
7376196 Carlson GP: Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol Lett. 1980 Jan;5(1):19-25.


Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, NADPH-cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo [a] pyrene hydroxylase.
2(0,0,0,2) Details
7420477 Smith EN, Carlson GP: Various pharmacokinetic parameters in relation to enzyme-inducing abilities of 1,2,4-trichlorobenzene and 1,2,4-tribromobenzene. J Toxicol Environ Health. 1980 Jul;6(4):737-49.


Cytochorme P-450 and NADPH-cytochrome c reductase were alsoinduced.
1(0,0,0,1) Details
6250253 Carlson GP: Induction of xenobiotic metabolism in rats by brominated diphenyl ethers administered for 90 days. Toxicol Lett. 1980 Aug;6(3):207-12.

The administration of doses as low as 0.78 mu mol/kg/day p.o. for 90 dys of the commercial fire retardants pentabromodiphenyl ehter and octabromodiphenyl ether to rats resulted in increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification and p-nitroanisole demethylation.
This dose of pentabromodiphenyl ehter and higher doses of octabromodiphenyl ether also increased cytochrome P-450 and NADPH cytochrome c reductase.
1(0,0,0,1) Details
102051 Carlson GP: Effect of trichlorophenols on xenobiotic metabolism in the rat. Toxicology. 1978 Oct;11(2):145-51.


Only 2,4,5-trichlorophenol at the highest dose decreased microsomal NADPH-cytochrome c reductase activity and cytochrome P-450 content.
1(0,0,0,1) Details
6778679 Carlson GP, Smith EN, Johnson KM: Induction of xenobiotic metabolism in rat liver by chlorinated biphenyl ether isomers. Drug Chem Toxicol. 1980;3(3):293-303.


Decachlorodiphenyl ether caused increases in EPN detoxification, NADPH cytochrome c reductase and cytochrome P-450 but did not alter aryl hydrocarbon hydroxylase (AHH).
0(0,0,0,0) Details