| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | leptophos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9823777 | Tian Y, Xie XK, Piao FY, Yamauchi T: Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. Tohoku J Exp Med. 1998 Jul;185(3):161-71. Ratios of NTE inhibition/AChE inhibition were higher in the leptophos group (0.91-1.24) and TOCP group (1.13-2.45) than in the dipterex group (0.25-0.79). |
112(1,2,2,2) | Details |
| 2432215 | Soliman SA, Curley A, Farmer J, Novak R: In vivo inhibition of chicken brain acetylcholinesterase and neurotoxic esterase in relation to the delayed neurotoxicity of leptophos and cyanofenphos. J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):211-24. |
64(0,2,2,4) | Details |
| 1581539 | Maxwell DM, Brecht KM: Quantitative structure-activity analysis of acetylcholinesterase inhibition by oxono and thiono analogues of organophosphorus compounds. Chem Res Toxicol. 1992 Jan-Feb;5(1):66-71. A comparison of the bimolecular rate constants (ki) for inhibition of electric eel acetylcholinesterase (AChE) by the oxono (i.e., P=O) and thiono (i.e., P=S) analogues of parathion, methylparathion, leptophos, fonofos, sarin, and soman revealed that the oxono/thiono ratios of ki values varied from 14 for soman to 1240 for parathion. |
35(0,1,1,5) | Details |
| 12742374 | Yen JH, Tsai CC, Wang YS: Separation and toxicity of enantiomers of organophosphorus insecticide leptophos. Ecotoxicol Environ Saf. 2003 Jun;55(2):236-42. In the inhibition test of acetylcholinesterase, the IC (50) values of (+)-leptophos, (-)-leptophos, and (+/-)-leptophos were 14.01, 24.32, and 13.22 gmL (-1), respectively. |
32(0,1,1,2) | Details |
| 12638169 | Konno N: [Neurotoxicity of organophosphorus and dithiocarbamate compounds] . Nippon Eiseigaku Zasshi. 2003 Jan;57(4):645-54. The major neurotoxicities of OPs were acute toxicity produced by the acetylcholine esterase (AChE) inhibiting action of OPs and delayed neurotoxicity produced by such OPs as leptophos and TOCP. |
31(0,1,1,1) | Details |
| 6188603 | Aldous CN, Farr CH, Sharma RP: Effects of leptophos on rat brain levels and turnover rates of biogenic amines and their metabolites. Ecotoxicol Environ Saf. 1982 Dec;6(6):570-6. Leptophos is a potent acetylcholinesterase inhibitor which causes delayed central-peripheral neuropathy. |
31(0,1,1,1) | Details |
| 7685784 | Anthony J: Acetylcholinesterase activity and degenerative changes in various segments of the spinal cord of hens induced by ingestion of subchronic levels of leptophos. J Environ Sci Health B. 1993 Jun;28(3):275-90. |
20(0,0,3,5) | Details |
| 2449534 | Farage-Elawar M, Francis BM: Effects of multiple dosing of fenthion, fenitrothion, and desbromoleptophos in young chicks. J Toxicol Environ Health. 1988;23(2):217-28. The effects of multiple doses of desbromoleptophos, fenitrothion, and pure fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of sensitivity to organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
5(0,0,0,5) | Details |
| 2439699 | Farage-Elawar M, Francis BM: Acute and delayed effects of fenthion in young chicks. J Toxicol Environ Health. 1987;21(4):455-69. The effects of desbromoleptophos, fenitrothion, and fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
5(0,0,0,5) | Details |
| 10321902 | Barber D, Correll L, Ehrich M: Comparative effectiveness of organophosphorus protoxicant activating systems in neuroblastoma cells and brain homogenates. J Toxicol Environ Health A. 1999 May 14;57(1):63-74. The ability of and rat liver microsomes (RLM) to convert organophosphorus (OP) protoxicants to esterase inhibitors was determined by measuring acetylcholinesterase (AChE) and neuropathy target esterase (NTE) inhibition. OP protoxicants examined included tri-o-tolyl (TOTP), O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN), leptophos, fenitrothion, fenthion, and malathion. |
4(0,0,0,4) | Details |
| 2453943 | Farage-Elawar M, Francis BM: Effects of fenthion, fenitrothion and desbromoleptophos on gait, acetylcholinesterase, and neurotoxic esterase in young chicks after in ovo exposure. Toxicology. 1988 May;49(2-3):253-61. |
3(0,0,0,3) | Details |
| 89138 | Hussain MA, Oloffs PC: effects of leptophos (PhosvelR) in chickens and rats following chronic low-level feeding. J Environ Sci Health B. 1979;14(4):367-82. Erythrocyte acetylcholinesterase (AChE) of the chickens given both doses was significantly depressed at first, then increased, and later dropped to control levels. |
3(0,0,0,3) | Details |
| 6169754 | El-Sebae AH, Soliman SA, Ahmed NS, Curley A: Biochemical interaction of six OP delayed neurotoxicants with several neurotargets. J Environ Sci Health B. 1981;16(4):465-74. Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. |
2(0,0,0,2) | Details |
| 1710763 | Farage-Elawar M, Duffy JS, Francis BM: Developmental toxicity of desbromoleptophos in chicks: enzyme inhibition, malformations and functional deficits. Neurotoxicol Teratol. 1991 Jan-Feb;13(1):91-7. The relationship among inhibition of acetylcholinesterase (AChE), inhibition of neuropathy target enzyme (NTE), and developmental toxicity of the organophosphorus ester desbromoleptophos (DBL) was evaluated in chicks exposed on day 3 or day 15 of incubation or 10 days posthatching. |
2(0,0,0,2) | Details |
| 438464 | El-Sebae AH, Soliman SA, Ahmed NS: Delayed neuropathy in sheep by the phosphonothioate insecticide cyanofenphos. J Environ Sci Health B. 1979;14(3):247-63. In weekly blood samples, AChE -sterase) and MAO (monoamine oxidase) activities were inhibited depending upon level of dosing and time interval. |
2(0,0,0,2) | Details |
| 10509429 | Abdelsalam EB: potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2. Leptophos was used as a reference agent. All compounds were administered at high single oral doses and the NTE and acetylcholinesterase (AchE) activities were measured at 24 h and 6 w later. |
1(0,0,0,1) | Details |
| 63268 | Lee PW, Fukuto TR: Penetration and comparative metabolism of leptophos in susceptible and resistant houseflies. Arch Environ Contam Toxicol. 1976;4(4):443-55. |
0(0,0,0,0) | Details |
| 2446940 | Gant DB, Eldefrawi ME, Eldefrawi AT: Action of organophosphates on GABAA receptor and voltage-dependent channels. Fundam Appl Toxicol. 1987 Nov;9(4):698-704. The industrial organophosphate tri-o-cresyl and the anticholinesterase organophosphate insecticides leptophos, leptophos oxon, and O-ethyl O- phenylphosphonothioate inhibited -regulated channels and bound with high affinity to the voltage-dependent channels (IC50 = 0.3 to 8.7 microM). |
0(0,0,0,0) | Details |