| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | leptophos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. Baseline activities of the major target esterases, i.e., cholinesterase, carboxylesterase, and neurotoxic esterase, were assayed in mouse and several human neural candidate cell lines. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). |
1(0,0,0,1) | Details |
| 72085 | Bradway DE, Shafik TM, Lores EM: Comparison of cholinesterase activity, residue levels, and urinary metabolite excretion of rats exposed to organophosphorus pesticides. J Agric Food Chem. 1977 Nov-Dec;25(6):1353-8. |
1(0,0,0,1) | Details |
| 6178187 | Moroi K, Kuga T: Inhibitory effect of leptophos on carboxylesterase (isocarboxazid amidase) in rat liver. Toxicol Lett. 1982 Apr;11(1-2):81-5. |
0(0,0,0,0) | Details |
| 565668 | Obersteiner EJ, Sharma RP: Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures. Can J Comp Med. 1978 Jan;42(1):80-8. Concentrations that produced half-maximal effects ranged from 1 x 10 (-6) M (severely toxic) for methylparathian, diazinon, paraoxon, mevinphos, diisopropylfluorophosphate, tri-o-tolyl and its mixed isomers to a 1 x 10 (-3) M (intermediate) for malathion, leptophos, coumaphos, mono- and dicrotophos. |
0(0,0,0,0) | Details |
| 6154073 | Riskallah MR: Reduced sensitivity of cholinesterase as a factor of resistance in leptophos selected strain in the Egyptian cotton leafworm. J Environ Sci Health B. 1980;15(2):181-92. On the other hand, there was a considerable degree of insensitivity of cholinesterase to inhibition by leptophos-oxon, methyl paraoxon, cyolane, cytrolane, monocrotophos, and matacil in larvae of the resistant strain. |
115(1,2,2,5) | Details |
| 12742374 | Yen JH, Tsai CC, Wang YS: Separation and toxicity of enantiomers of organophosphorus insecticide leptophos. Ecotoxicol Environ Saf. 2003 Jun;55(2):236-42. From the inhibition test of butyrylcholinesterase, the half-inhibitory concentrations, IC (50), of (+)-leptophos, (-)-leptophos, and (+/-)-leptophos were 0.241, 1.17, and 1.05 gmL (-1), respectively. |
82(1,1,1,2) | Details |
| 72768 | El-Sebae AH, Soliman SA, Elamayem MA, Ahmed NS: Neurotoxicity of organophosphorus insecticides Leptophos and EPN. J Environ Sci Health B. 1977;12(4):269-87. The results revealed that all five compounds were inhibitors of cholinesterase, but only Leptophos and EPN were shown to be potent inhibitors for both neurotoxic esterase and monoamine oxidase in the mouse brain. |
32(0,1,1,2) | Details |
| 2446940 | Gant DB, Eldefrawi ME, Eldefrawi AT: Action of organophosphates on GABAA receptor and voltage-dependent channels. Fundam Appl Toxicol. 1987 Nov;9(4):698-704. The industrial organophosphate tri-o-cresyl and the anticholinesterase organophosphate insecticides leptophos, leptophos oxon, and O-ethyl O- phenylphosphonothioate inhibited -regulated channels and bound with high affinity to the voltage-dependent channels (IC50 = 0.3 to 8.7 microM). |
31(0,1,1,1) | Details |
| 1200722 | Davies JE, Barquet A, Freed VH, Haque R, Morgade C, Sonneborn RE, Vaclavek C: Human pesticide poisonings by a fat-soluble organophosphate insecticide. Arch Environ Health. 1975 Dec;30(12):608-13. Two patients died, and in the three survivors, cholinesterase symptoms persisted for five to 48 days. The partition coefficient of dichlofenthion in fat was 20 times greater than parathion, and exceeded only by leptophos. |
2(0,0,0,2) | Details |
| 6470929 | Matsubara T, Horikoshi I: Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds. J Pharmacobiodyn. 1984 May;7(5):322-8. The plasma ChEs inhibited by surecide, salithion and leptophos, which contain no O,O-dimethyl moiety, were not reactivated or only slightly so. |
2(0,0,0,2) | Details |
| 7338954 | Nishio A, Uyeki EM: Induction of sister chromatid exchanges in Chinese hamster ovary cells by organophosphate insecticides and their analogs. J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):939-46. Induction of sister chromatid exchanges (SCEs) in cultures of Chinese hamster ovary cells by 10 anticholinesterase organophosphate insecticides was investigated. The insecticides were two phosphates (dichlorvos and dicrotophos), four -containing organophosphates (malathion, parathion, leptophos, and diazinon), and four analogs of the latter (malaoxon, paraoxon, leptophosoxon, and diazoxon). |
1(0,0,0,1) | Details |
| 6205472 | Hoffman DJ, Sileo L, Murray HC: Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards. Toxicol Appl Pharmacol. 1984 Aug;75(1):128-36. Brain acetylcholinesterase, plasma cholinesterase, and plasma alkaline phosphatase were significantly inhibited as well. Additional ducks were exposed in a similar manner to 60-, 270-, or 540-ppm leptophos (phosphonothioic acid O-4-bromo-2,5-dichlorophenyl-O-methylphenyl ester) which resulted in similar behavioral, biochemical, and histopathological alterations. |
1(0,0,0,1) | Details |
| 56273 | Freed VH, Matin MA, Fang SC, Kar PP: Role of striatal in delayed effects of organophosphorus compounds. Eur J Pharmacol. 1976 Jan;35(1):229-32. Treatment with Leptophos for the same period produced slight motor dysfunction and a small but significant reduction in the level of striatal The cholinesterase activity of corpus striatum was inhibited by all the compounds. |
1(0,0,0,1) | Details |
| 6169754 | El-Sebae AH, Soliman SA, Ahmed NS, Curley A: Biochemical interaction of six OP delayed neurotoxicants with several neurotargets. J Environ Sci Health B. 1981;16(4):465-74. Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. |
1(0,0,0,1) | Details |