Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
6795294 Pala A, Marinelli G, Gregorio D, Spampinato G, Moro M, Carenza L: Substantial amounts of gonadotrophin-like materials in sera of normal subjects. J Endocrinol. 1981 Nov;91(2):179-88.

Ultrafiltration of human sera resulted in increased levels of human chorionic gonadotrophin (hCH), LH and FSH measured by radioimmunoassay.
The effect was greatly enhanced by chromatography of serum through Sepharose-protein A (which specifically binds immunoglobulin G) followed by ultrafiltration of the unretarded fractions.
1(0,0,0,1) Details
10670628 Brenner P, Reichenspurner H, Schmoeckel M, Wimmer C, Rucker A, Eder V, Meiser B, Hinz M, Felbinger T, Muller-Hocker J, Hammer C, Reichart B: IG-therasorb immunoapheresis in orthotopic xenotransplantation of baboons with landrace pig hearts. Transplantation. 2000 Jan 27;69(2):208-14.


To prevent HXR after orthotopic xenotransplantation (oXHTx), the immunoglobulins (Ig) and natural antibodies were adsorbed to reusable Ig-Therasorb immunoadsorption (IA) columns.
1(0,0,0,1) Details
12534552 Weichel M, Schmid-Grendelmeier P, Rhyner C, Achatz G, Blaser K, Crameri R: Immunoglobulin E-binding and skin test reactivity to hydrophobin HCh-1 from Cladosporium herbarum, the first allergenic cell wall component of fungi. Clin Exp Allergy. 2003 Jan;33(1):72-7.
81(1,1,1,1) Details
11266329 Daniel V, Huber W, Bauer K, Suesal C, Conradt C, Opelz G: Associations of blood levels of PCB, HCHS, and HCB with numbers of lymphocyte subpopulations, in vitro lymphocyte response, plasma cytokine levels, and immunoglobulin autoantibodies. Environ Health Perspect. 2001 Feb;109(2):173-8.

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10612380 Brenner P, Hinz M, Huber H, Schmoeckel M, Reichenspurner H, Meiser B, Hammer C, Reichart B: Effects of prolonged cold storage time in xenotransplantation. J Heart Lung Transplant. 1999 Dec;18(12):1211-7.


IA removed immunoglobulins IgG, IgM and IgA from the perfusate.
2(0,0,0,2) Details
12027075 Garcia-Gonzalez JJ, Bartolome-Zavala B, Fernandez-Melendez S, Barcelo-Munoz JM, Miranda Paez A, Carmona-Bueno MJ, Vega-Chicote JM, Negro Carrasco MA, Ameal Godoy A, Pamies Espinosa R: Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol. 2002 May;88(5):518-22.


The molecular weights of the main immunoglobulin (Ig) E-binding proteins in aniseed extracts were approximately 48, 42, 39, 37, 34, 33, and 20 kD.
1(0,0,0,1) Details
11112063 Brenner P, Reichenspurner H, Schmoeckel M, Wimmer C, Rucker A, Eder V, Meiser B, Hinz M, Felbinger T, Hammer C, Reichart B: Prevention of hyperacute xenograft rejection in orthotopic xenotransplantation of pig hearts into baboons using immunoadsorption of antibodies and complement factors. Transpl Int. 2000;13 Suppl 1:S508-17.


To prevent hyperacute xenograft rejection (HXR) caused by preformed natural antibodies (XNAb) after orthotopic heart xenotransplantation (oXHTx) of landrace pig hearts into baboons, we used immunoadsorption of immunoglobulins IgG, IgM and IgA and complement with the reusable Ig-Therasorb column.
1(0,0,0,1) Details
15831097 Karmaus W, Brooks KR, Nebe T, Witten J, Obi-Osius N, Kruse H: Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study. Environ Health. 2005 Apr 14;4(1):5.


METHODS: We investigated whether the organochlorine compounds (OC) dichlorodiphenylethylene (DDE), hexachlorobenzene (HCB), hexachlorocyclohexane (gamma-HCH), the sum of polychlorinated biphenyls (SigmaPCBs) and Pb were associated with immune markers such as immunoglobulin (Ig) levels, white blood cell (WBC), counts of lymphocytes; eosinophils and their eosinophilic granula as well as IgE count on basophils.
1(0,0,0,1) Details
2430350 Kashyap SK: Health surveillance and biological monitoring of pesticide formulators in India. Toxicol Lett. 1986 Oct;33(1-3):107-14.


Changes in the liver enzymes ornithine carbamyl transferase (OCT), gamma-glutamyl transpeptidase (GGTP), leucine aminopeptidase (LAP) and in immunoglobulin M (IgM) showed possible effects on liver and humoral immunity.
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