Protein Information

Name ErbB 2
Synonyms C erb B2; NEU; C erb B2/neu protein; C erbB 2; CD340 antigen; ERBB 2; ERBB2; ErbB 2 isoform a…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
11222871 Tessier DM, Matsumura F: Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. Toxicol Sci. 2001 Mar;60(1):38-43.

 4(0,0,0,4) Details
10487416 Hatakeyama M, Matsumura F: Correlation between the activation of Neu tyrosine kinase and promotion of foci formation induced by selected organochlorine compounds in the MCF-7 model system. J Biochem Mol Toxicol. 1999;13(6):296-302.


In our previous study, two representative organochlorines, 1,1,1-trichloro 2-o-chlorophenyl-2'-p-chlorophenyl ethane (o,p'-DDT) and beta-1,2,3,4,5,6-hexachlorocyclohexane (beta HCH), were found to directly activate the protein tyrosine kinase of Neu (c-erbB-2 proto-oncogene product) immunoprecipitates isolated from MCF-7 breast cancer cells.		 1(0,0,0,1) Details