| Name | PC 3 |
|---|---|
| Synonyms | PC 3; secreted microprotein PC 3; secreted microprotein PC 3s |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14688026 | Kalantzi OI, Hewitt R, Ford KJ, Cooper L, Alcock RE, Thomas GO, Morris JA, McMillan TJ, Jones KC, Martin FL: Low dose induction of micronuclei by lindane. . Carcinogenesis. 2004 Apr;25(4):613-22. Epub 2003 Dec 19. Chromosomal damage in MCF-7 breast cells and PC-3 prostate cells was assessed using the cytokinesis block micronucleus assay. |
3(0,0,0,3) | Details |
| 11222871 | Tessier DM, Matsumura F: Increased ErbB-2 kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. Toxicol Sci. 2001 Mar;60(1):38-43. In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil. o,p'-DDT also causes phosphorylation of mitogen-activated protein kinase (MAPK) and cellular proliferation of the androgen-dependent LNCaP line. |
1(0,0,0,1) | Details |
| 10696776 | Schrader TJ, Cooke GM: Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol Sci. 2000 Feb;53(2):278-88. In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectants selected. |
2(0,0,0,2) | Details |