Protein Information

Name ferritin (protein family or complex)
Synonyms Ferritin; Ferritins

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
12459200 Pham DQ, Shaffer JJ, Chavez CA, Douglass PL: Identification and mapping of the promoter for the gene encoding the ferritin heavy-chain homologue of the yellow fever mosquito Aedes aegypti. Insect Biochem Mol Biol. 2003 Jan;33(1):51-62.

Our transfection assays and DNase I footprinting analyses show that the mosquito ferritin HCH-gene contains regulatory elements both upstream and downstream of the transcriptional start site.
7(0,0,1,2) Details
15325344 Kim SR, Lee KS, Yoon HJ, Park NS, Lee SM, Kim I, Seo SJ, Sohn HD, Jin BR: Molecular cloning, expression and characterization of cDNAs encoding the ferritin subunits from the beetle, Apriona germari. Comp Biochem Physiol B Biochem Mol Biol. 2004 Aug;138(4):423-33.

7(0,0,0,7) Details
15455041 Dunkov BC, Georgieva T, Yoshiga T, Hall M, Law JH: Aedes aegypti ferritin heavy chain homologue: feeding of iron or blood influences message levels, lengths and subunit abundance. J Insect Sci. 2002;2:7. Epub 2002 Apr 22.


Secreted ferritin in the mosquito, Aedes aegypti, has several subunits that are the products of at least two genes, one encoding a homologue of the vertebrate heavy chain (HCH) and the other the light chain homologue (LCH).
7(0,0,0,7) Details
11804801 Georgieva T, Dunkov BC, Dimov S, Ralchev K, Law JH: Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types. Insect Biochem Mol Biol. 2002 Mar 1;32(3):295-302.

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10077577 Georgieva T, Dunkov BC, Harizanova N, Ralchev K, Law JH: Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2716-21.

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16503479 Geiser DL, Zhang D, Winzerling JJ: Secreted ferritin: mosquito defense against iron overload? . Insect Biochem Mol Biol. 2006 Mar;36(3):177-87. Epub 2006 Jan 11.

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10619605 Dunkov BC, Georgieva T: Organization of the ferritin genes in Drosophila melanogaster. DNA Cell Biol. 1999 Dec;18(12):937-44.

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12950250 Geiser DL, Chavez CA, Flores-Munguia R, Winzerling JJ, Pham DQ: Aedes aegypti ferritin. . Eur J Biochem. 2003 Sep;270(18):3667-74.

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15101063 Kim HJ, Yun CY, Cheon HM, Chae B, Lee IH, Park SJ, Kang YJ, Seo SJ: Hyphantria cunea ferritin heavy chain homologue: cDNA sequence and mRNA expression. Arch Insect Biochem Physiol. 2004 May;56(1):21-33.


We have sequenced a cDNA clone encoding a 26-kDa ferritin subunit, which was heavy chain homologue (HCH), in fall webworm, Hyphantria cunea.
7(0,0,0,7) Details
14509834 Huang WH, Guo HB, Huang XY, Sun FZ: Two types of new ferritin cDNA sequences from Xenopus laevis germinal vesicle oocytes. DNA Seq. 2003 Jun;14(3):211-4.

One of them is the ferritin light chain homologous (LCH), which is reported for the first time in Xenopus and the other is the ferritin heavy chain homologous (HCH) that is first reported in Xenopus GV oocyte.
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15926891 Pham DQ, Douglass PL, Chavez CA, Shaffer JJ: Regulation of the ferritin heavy-chain homologue gene in the yellow fever mosquito, Aedes aegypti. Insect Mol Biol. 2005 Jun;14(3):223-36.

In the yellow fever mosquito Aedes aegypti, the ferritin heavy-chain homologue (HCH) gene is induced by blood feeding.
This suggests that ferritin may serve as a cytotoxic protector against the oxidative challenge of the blood meal and may be essential for the survival of the insect.
2(0,0,0,2) Details