| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6198504 | Yamamoto T, Egashira T, Yamanaka Y, Yoshida T, Kuroiwa Y: Initial metabolism of gamma-hexachlorocyclohexane (gamma-HCH) by rat liver microsomes. J Pharmacobiodyn. 1983 Oct;6(10):721-8. These results suggest that cytochrome P-450 is involved in this reaction. |
2(0,0,0,2) | Details |
| 2575289 | Kitchin KT, Brown JL: Biochemical studies of promoters of carcinogenesis in rat liver. . Teratog Carcinog Mutagen. 1989;9(5):273-85. The seven noncarcinogens produced several biochemical effects at doses of 1/5 the LD50: increased serum alanine aminotransferase activity (SGPT) (caprolactam and DEDTC), decreased hepatic cytochrome P-450 content (DEDTC), and increased hepatic ODC activity (8-hydroxyquinoline and DEDTC). |
2(0,0,0,2) | Details |
| 10514269 | Rattan K, Shanker R, Khanna P, Atkins WM: Stress Survival of a Genetically Engineered Pseudomonas in Soil Slurries: Cytochrome P-450cam-Catalyzed Dehalogenation of Chlorinated Hydrocarbons. Biotechnol Prog. 1999 Oct 1;15(5):958-962. These results indicate that GEMs can be constructed with broad substrate range detoxification catalysts such as cytochrome P-450 for remediation. |
1(0,0,0,1) | Details |
| 1712275 | Beurskens JE, Stams AJ, Zehnder AJ, Bachmann A: Relative biochemical reactivity of three hexachlorocyclohexane isomers. Ecotoxicol Environ Saf. 1991 Apr;21(2):128-36. The rate and mechanisms of degradation of three hexachlorocyclohexane (HCH) isomers were studied with rat liver cytochrome P450, which is known to react with chlorinated compounds in the presence and absence of molecular |
1(0,0,0,1) | Details |
| 1708174 | Barros SB, Simizu K, Junqueira VB: Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicol Lett. 1991 Apr;56(1-2):137-44. Rats treated with diets containing 20 ppm of alpha- or gamma-hexachlorocyclohexane (HCH) for 15 or 30 days showed increased levels of liver cytochrome P-450 followed by increased production of both thiobarbituric acid reactants by liver homogenates and microsomes and production by liver microsomes. |
1(0,0,0,1) | Details |
| 6209737 | Seifert J, Machkova Z: Effect of fasting on the metabolism of nucleotides in the liver of intact and alpha-hexachlorocyclohexane-treated rats. Physiol Bohemoslov. 1984;33(5):403-10. Fasting has an additive effect on the increase of cytochrome P-450 level in the alpha-HCH treated rats. |
1(0,0,0,1) | Details |
| 8671720 | Mattioli F, Robbiano L, Adamo D, Federa R, Martelli A, Brambilla G: Genotoxic effects of alpha-hexachlorocyclohexane in primary cultures of rodent and human hepatocytes. Mutagenesis. 1996 Jan;11(1):79-83. The reduction in the frequency of DNA breaks observed in rat hepatocytes simultaneously exposed to suggests that alpha-HCH is transformed into reactive species by a cytochrome P450-dependent reaction. |
1(0,0,0,1) | Details |
| 54245 | Seifert J, Vacha J: Sex-dependent differences in the biosynthesis of pyrimidine nucleotides in rat liver after repeated administration of alpha-hexachlorocyclohexane. Drug Metab Dispos. 1975 Nov-Dec;3(6):430-6. Simultaneously, the level of liver microsomal cytochrome P-450 is increased after the administration of alpha-HCH more in males than in females. |
1(0,0,0,1) | Details |
| 2471492 | Kumar A, Dwivedi PP: Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes. Arch Toxicol. 1988;62(6):479-81. It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold. |
88(1,1,2,3) | Details |
| 77193 | Seifert J, Vacha J, Seifertova M: Liver growth, biosynthesis of nucleotides and level of cytochrome P-450 in rat liver after administration of alpha-hexachlorocyclohexane. Chem Biol Interact. 1978 Feb;20(2):227-38. |
3(0,0,0,3) | Details |