Protein Information

Name PLA2
Synonyms 85 kDa calcium independent phospholipase A2; PLA 2; PLA2; CaI PLA2; GVI; GVI PLA2; Group VI phospholipase A2; INAD 1…

Compound Information

Name HCH
CAS 1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
3196359 Yamada K, Saltarelli MD, Coyle JT: Involvement of phospholipase A2 in the regulation of [3H] hemicholinium-3 binding. Biochem Pharmacol. 1988 Nov 15;37(22):4367-73.

Incubation of striatal synaptic membranes with bee venom PLA2 resulted in a concentration-dependent increase in the specific binding of [3H] HCh-3.
307(3,5,5,7) Details
2732947 Yamada K, Saltarelli MD, Coyle JT: Specificity of the activation of [3H] hemicholinium-3 binding by phospholipase A2. J Pharmacol Exp Ther. 1989 Jun;249(3):836-42.

In contrast to the increase of [3H] HCh-3 binding, the specific binding of both [3H] desipramine and [3H] mazindol was decreased by PLA2 treatment.
256(2,5,5,6) Details
2299401 Saltarelli MD, Yamada K, Coyle JT: Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake. J Neurosci. 1990 Jan;10(1):62-72.

These results support the involvement of PLA2 and subsequent fatty acid release in the increase of 3H-HCh-3 binding in cholinergic neurons and suggest that activation of PLA2 may be the penultimate step in regulating the velocity of sodium-dependent choline transport.
112(1,2,2,2) Details