| Name | gamma aminobutyric acid receptors (protein family or complex) |
|---|---|
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| Name | gamma-HCH |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1377327 | Woodward RM, Polenzani L, Miledi R: Effects of hexachlorocyclohexanes on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by RNA from mammalian brain and retina. Mol Pharmacol. 1992 Jun;41(6):1107-15. |
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| 18446586 | Law RJ, Lightstone FC: Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites. Int J Neurosci. 2008 May;118(5):705-34. |
2(0,0,0,2) | Details |
| 8949935 | Nagata K, Huang CS, Hamilton BJ, Carter DB, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. Brain Res. 1996 Oct 28;738(1):131-7. |
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| 9590437 | Vale C, Damgaard I, Sunol C, Rodriguez-Farre E, Schousboe A: Cytotoxic action of lindane in cerebellar granule neurons is mediated by interaction with inducible GABA (B) receptors. J Neurosci Res. 1998 May 1;52(3):286-94. However, in THIP-treated cultures, lindane-induced cytotoxicity was found to be mediated by an action of the insecticide on GABA receptors. |
1(0,0,0,1) | Details |
| 18651916 | Hirata K, Ishida C, Eguchi Y, Sakai K, Ozoe F, Ozoe Y, Matsuda K: Role of a serine residue (S278) in the pore-facing region of the housefly -gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol Biol. 2008 Aug;17(4):341-50. Gamma-hexachlorocyclohexane (gamma-HCH), fipronil and picrotoxinin are noncompetitive antagonists (NCAs) of -gated channels (GluCls), yet their potencies are weaker than those on gamma-aminobutyric acid receptors (GABARs). |
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| 8750965 | Nagata K, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor-chloride channel complex in rat dorsal root ganglion neurons. Brain Res. 1995 Dec 15;704(1):85-91. |
1(0,0,0,1) | Details |
| 10397639 | Vale C, Vilaro MT, Rodriguez-Farre E, Sunol C: Effects of the conformationally restricted analogues, cis- and trans-4-aminocrotonic acid, on neurotransmission in primary neuronal cultures. J Neurosci Res. 1999 Jul 1;57(1):95-105. The results presented here show that p-1 subunits, and thus GABAc receptors, may represent a very minor population of GABA receptors in these neuronal preparations. |
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| 1371151 | Vendrell M, Tusell JM, Serratosa J: c-fos expression as a model for studying the action of hexachlorocyclohexane isomers in the CNS. J Neurochem. 1992 Mar;58(3):862-9. Pentylenetetrazole and picrotoxin, a known gamma-aminobutyric acid-receptor antagonist, have also been considered. |
1(0,0,0,1) | Details |