Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name gamma-HCH
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
6198504 Yamamoto T, Egashira T, Yamanaka Y, Yoshida T, Kuroiwa Y: Initial metabolism of gamma-hexachlorocyclohexane (gamma-HCH) by rat liver microsomes. J Pharmacobiodyn. 1983 Oct;6(10):721-8.


These results suggest that cytochrome P-450 is involved in this reaction.
2(0,0,0,2) Details
10514269 Rattan K, Shanker R, Khanna P, Atkins WM: Stress Survival of a Genetically Engineered Pseudomonas in Soil Slurries: Cytochrome P-450cam-Catalyzed Dehalogenation of Chlorinated Hydrocarbons. Biotechnol Prog. 1999 Oct 1;15(5):958-962.


These results indicate that GEMs can be constructed with broad substrate range detoxification catalysts such as cytochrome P-450 for remediation.
1(0,0,0,1) Details
1712275 Beurskens JE, Stams AJ, Zehnder AJ, Bachmann A: Relative biochemical reactivity of three hexachlorocyclohexane isomers. Ecotoxicol Environ Saf. 1991 Apr;21(2):128-36.


The rate and mechanisms of degradation of three hexachlorocyclohexane (HCH) isomers were studied with rat liver cytochrome P450, which is known to react with chlorinated compounds in the presence and absence of molecular oxygen.
1(0,0,0,1) Details