| Name | chloride channel (protein family or complex) |
|---|---|
| Synonyms | chloride channel |
| Name | gamma-HCH |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2451320 | Fishman BE, Gianutsos G: CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse. Toxicol Appl Pharmacol. 1988 Mar 30;93(1):146-53. However, acute exposure to alpha- or delta-HCH inhibited the seizure activity due to PTZ but increased that of PIC. gamma-, alpha-, and delta-HCH inhibited the binding of 3H-TBOB (a ligand for the -A receptor linked chloride channel) to mouse whole brain membranes with IC50 values of 4.6, 20.0, and 31.8 microM, respectively. |
3(0,0,0,3) | Details |
| 8750965 | Nagata K, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor-chloride channel complex in rat dorsal root ganglion neurons. Brain Res. 1995 Dec 15;704(1):85-91. |
3(0,0,0,3) | Details |
| 17201770 | Eguchi Y, Ihara M, Ochi E, Shibata Y, Matsuda K, Fushiki S, Sugama H, Hamasaki Y, Niwa H, Wada M, Ozoe F, Ozoe Y: Functional characterization of Musca - and -gated channels expressed independently and coexpressed in Xenopus oocytes. Insect Mol Biol. 2006 Dec;15(6):773-83. Genes encoding subunits of two LGICs, -gated chloride channel (MdGluCl-alpha) and a -gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). |
2(0,0,0,2) | Details |
| 2443783 | Fishman BE, Gianutsos G: Opposite effects of different hexachlorocyclohexane (lindane) isomers on cerebellar cyclic GMP: relation of cyclic GMP accumulation to seizure activity. Life Sci. 1987 Oct 5;41(14):1703-9. All three HCH isomers inhibited the binding of 3H-TBOB (a ligand for the -A-receptor linked chloride channel) in mouse cerebellum. |
2(0,0,0,2) | Details |
| 12645305 | Sauviat MP, Pages N: [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane] . J Soc Biol. 2002;196(4):339-48. Lindane exerts a stimulating action on synaptic transmission and inhibits the current activated by gamma-amino of many muscular and nervous preparations by interacting with the receptors -chloride channel complex. |
1(0,0,0,1) | Details |
| 8949935 | Nagata K, Huang CS, Hamilton BJ, Carter DB, Narahashi T: Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. Brain Res. 1996 Oct 28;738(1):131-7. We have recently demonstrated by patch clamp experiments that the four isomers of hexachlorocyclohexane (HCH), alpha-, beta-, gamma- and delta-HCH insecticides, modulated the kinetics of the GABAA receptor-chloride channel complex of rat dorsal root ganglion neurons. |
1(0,0,0,1) | Details |
| 18651916 | Hirata K, Ishida C, Eguchi Y, Sakai K, Ozoe F, Ozoe Y, Matsuda K: Role of a serine residue (S278) in the pore-facing region of the housefly -gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol Biol. 2008 Aug;17(4):341-50. |
1(0,0,0,1) | Details |
| 2440413 | Fishman BE, Gianutsos G: Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures. Arch Toxicol. 1987 Apr;59(6):397-401. The in vitro data suggest that the site responsible for the decrease in seizure activity 24 h after gamma-HCH may be the -A receptor-linked chloride channel. |
1(0,0,0,1) | Details |