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Tryphonas H, Bondy G, Hodgen M, Coady L, Parenteau M, Armstrong C, Hayward S, Liston V: Effects of cis-nonachlor, trans-nonachlor and chlordane on the immune system of Sprague-Dawley rats following a 28-day oral (gavage) treatment. Food Chem Toxicol. 2003 Jan;41(1):107-18.
Statistically significant (P <0.05) effects included: increased serum immunoglobulin M (IgM) levels in the chlordane-treated females at the 25 mg/kg dose (pairwise comparison); increased serum IgG (1) and IgG (2c) in the cis-nonachlor-treated males at the 2.5 and 25 mg/kg doses and increased serum IgG (2a) levels at all doses; increased serum IgG (2b) at the 25 mg/kg dose and decreased (dose-related) serum IgM levels in the cis-nonachlor-treated male rats; increased (linear trend) IgG (1) and IgG (2a) in the cis-nonachlor-treated females with effects on IgG (2a) significant at the 25 mg/kg dose compared with control; increased serum IgG (2a) in the trans-nonachlor-treated male and female rats at the 2.5 mg/kg dose; increased absolute numbers (linear trend) of peripheral white blood cells, B lymphocytes, natural killer (NK) cells, T-suppressor/cytotoxic lymphocytes, and the double positive (T-helper/inducer, T-suppressor/cytotoxic) cells in the trans-nonachlor-treated females; increased (non-linear trend) lymphoproliferative activity in the Con A-stimulated splenocytes and decreased (linear trend) activity in the S. typhimurium mitogen-stimulated splenocytes of the cis-nonachlor-treated females; reduced resistance to L. monocytogenes in the cis-nonachlor (day 3, P=0.034)- and trans-nonachlor (day 2, P=0.0001)-treated females, and reduced (linear trend) NK cell activity in the cis-nonachlor-treated males. |
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