Protein Information

Name beta adrenergic receptor (protein family or complex)
Synonyms Beta adrenoceptor; Beta adrenoceptor; Beta adrenergic receptor; Beta adrenergic receptors; Beta adrenoceptor; Beta adrenoceptors; Beta adrenoceptors

Compound Information

Name 1-naphthol
CAS 1-naphthalenol

Reference List

PubMed Abstract RScore(About this table)
12404879 Jindal DP, Coumar MS, Bruni G, Massarelli P: Synthesis and beta 1-, beta 2-adrenergic receptor binding studies of 4-acylamino-substituted phenoxypropanolamine and 5-acylamino-substituted naphthyloxypropanolamine derivatives. Arzneimittelforschung. 2002;52(9):654-63.

The object of this study was to investigate the beta-adrenergic receptor binding affinity of 4-acylaminophenoxypropanolamine (10-15) and 5-acylaminonaphthyloxypropanolamine (21-24) derivatives, which were prepared from 4-aminophenol (5) and 5-amino-1-naphthol (16), respectively.
32(0,1,1,2) Details
16112140 Uwai K, Tani M, Ohtake Y, Abe S, Maruko A, Chiba T, Hamaya Y, Ohkubo Y, Takeshita M: Photodegradation products of propranolol: the structures and pharmacological studies. Life Sci. 2005 Dec 12;78(4):357-65. Epub 2005 Aug 19.

Propranolol (1), a beta-adrenergic receptor antagonist, is widely used for angina pectoris, arrhythmia, and hypertension.
In this study, we isolated three photodegraded products of propranolol (1): 1-naphthol (2), N-acetylpropranolol (3), and N-formylpropranolol (4).
2(0,0,0,2) Details
12818235 Kapoor M, Anand N, Koul S, Chimni SS, Manhas KS, Raina C, Parshad R, Taneja SC, Qazi GN: Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers. Bioorg Chem. 2003 Jun;31(3):259-69.

Herein, improvement in the preparation of racemic 1-chloro-3-(1-naphthyloxy)-2-propanol generated from 1-naphthol and epichlorohydrin are reported.
1(0,0,0,1) Details