Protein Information

Name MDR1
Synonyms ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS…

Compound Information

Name benzyladenine
CAS

Reference List

PubMed Abstract RScore(About this table)
12610223 Terasaka K, Shitan N, Sato F, Maniwa F, Ueda K, Yazaki K: Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. Plant Cell Physiol. 2003 Feb;44(2):198-200.

The benzyladenine-induced band in T. minus showed properties similar to those of human MDR1, including the recognition of berberine, which suggests that the ABC protein detected in T. minus takes this endogenous alkaloid as a putative substrate for transport.
31(0,1,1,1) Details
12620361 Terasaka K, Sakai K, Sato F, Yamamoto H, Yazaki K: Thalictrum minus cell cultures and ABC-like transporter. . Phytochemistry. 2003 Feb;62(3):483-9.

Cultured Thalictrum minus cells produce a benzylisoquinoline alkaloid, berberine, in the presence of benzyladenine, and excrete it into the culture medium.
The addition of several inhibitors of P-glycoprotein, a representative ABC transporter, induced the accumulation in of both berberine and calcein AM ATP-dependent manner.
2(0,0,0,2) Details