Protein Information

Name cyclin dependent kinase (protein family or complex)
Synonyms cyclin dependent kinase; cyclin dependent kinases

Compound Information

Name benzyladenine
CAS

Reference List

PubMed Abstract RScore(About this table)
12882273 Blagoeva E, Malbeck J, Gaudinova A, Vanek T, Vankova R: Cyclin-dependent kinase inhibitor, roscovitine, in combination with exogenous cytokinin, N6-benzyladenine, causes increase of cis-cytokinins in immobilized tobacco cells. Biotechnol Lett. 2003 Mar;25(6):469-72.
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16386795 Travnicek Z, Krystof V, Sipl M: Zinc (II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity. J Inorg Biochem. 2006 Feb;100(2):214-25. Epub 2006 Jan 4.

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9737000 Trehin C, Planchais S, Glab N, Perennes C, Tregear J, Bergounioux C: Cell cycle regulation by plant growth regulators: involvement of auxin and cytokinin in the re-entry of Petunia protoplasts into the cell cycle. Planta. 1998 Oct;206(2):215-24.

In order to understand the mode of action of auxins and cytokinins in the induction of cell division, the effects of the two plant growth regulators 2,4-dichlorophenoxyacetic acid (2,4-D) and N6-benzyladenine (BA) were investigated using mesophyll protoplasts of Petunia hybrida, cultivated in either complete medium or in medium deficient in cytokinin, auxin or both.
Roscovitine, a cyclin-dependent kinase (CDK) inhibitor, was found to block the cell cycle prior to entry into the S and M phases in the cultured P. hybrida protoplasts.
1(0,0,0,1) Details
15153188 Blagoeva E, Dobrev PI, Malbeck J, Motyka V, Strnad M, Hanus J, Vankova R: Cytokinin N-glucosylation inhibitors suppress deactivation of exogenous cytokinins in radish, but their effect on active endogenous cytokinins is counteracted by other regulatory mechanisms. Physiol Plant. 2004 Jun;121(2):215-222.

The latter ones, which function as potent inhibitors of cyclin-dependent kinases, have also been found to effectively inhibit cytokinin N-glucosylation.
Incubation (24 h) of de-rooted radish seedlings with inhibitors resulted in c. 50% decrease of the conversion of model cytokinins, [(3) H] dihydrozeatin and [(3) H] N (6)-benzyladenine, to the corresponding 7N-glucosides.
1(0,0,0,1) Details