Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
17687000 Shen QW, Zhu MJ, Tong J, Ren J, Du M: Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1395-403. Epub 2007 Aug 8.

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18434517 Wang H, Wu LJ, Zhang F, Zhuo M: Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28(17):4385-97.

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18412613 Wu LJ, Zhang XH, Fukushima H, Zhang F, Wang H, Toyoda H, Li BM, Kida S, Zhuo M: Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci. 2008 Apr;27(8):1923-32.

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19436069 Wang H, Fukushima H, Kida S, Zhuo M: Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex. J Biol Chem. 2009 Jul 10;284(28):18953-62. Epub 2009 May 12.

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17855357 Goransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K: Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.


However, in HeLa cells, which lack LKB1 but express the alternate upstream kinase calmodulin-dependent protein kinase kinase-beta, phosphorylation of AMPK and ACC in response to A-769662 still occurs.
1(0,0,0,1) Details
19826102 Deshmukh AS, Glund S, Tom RZ, Zierath JR: Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1388-94. Epub 2009 Oct 13.


The role of Ca (2+)-mediated signaling was tested using the Ca (2+)/calmodulin competitive inhibitor KN-93.
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20057367 Anavi S, Ilan E, Tirosh O, Madar Z: Infusion of a Lipid Emulsion Modulates AMPK and Related Proteins in Rat Liver, Muscle, and Adipose Tissues. Obesity (Silver Spring). 2010 Jan 7.


Muscles exposed to LE for 6 days exhibited increased AMPK and acetyl-CoA carboxylase (ACC) phosphorylation, along with a greater association between AMPK and Ca (2+)/calmodulin-dependent protein kinase kinase (CaMKK).
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19030775 Lee JY, Jeon BT, Shin HJ, Lee DH, Han JY, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS: Temporal expression of AMP-activated protein kinase activation during the kainic acid-induced hippocampal cell death. J Neural Transm. 2009 Jan;116(1):33-40. Epub 2008 Nov 22.


Immunoreactivity of Ca (2+)/calmodulin-dependent protein kinase kinasebeta (CaMKKbeta) was increased after KA treatment.
1(0,0,0,1) Details