Protein Information

Name serine threonine kinase
Synonyms PKU alpha; PKUa; PKUalpha; Protein kinase ubiquitous alpha; Serine/threonine kinase; Serine/threonine protein kinase tousled like 2; TLK 2; TLK2…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
17668379 Boland E, Clayton-Smith J, Woo VG, McKee S, Manson FD, Medne L, Zackai E, Swanson EA, Fitzpatrick D, Millen KJ, Sherr EH, Dobyns WB, Black GC: Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum. Am J Hum Genet. 2007 Aug;81(2):292-303. Epub 2007 Jun 13.

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19723093 Lee YK, Hwang JT, Lee MS, Kim YM, Park OJ: Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway. Ann N Y Acad Sci. 2009 Aug;1171:484-8.

Recently, the evolutionarily conserved serine/threonine kinase, AMPK, has emerged as a possible target molecule of tumor control.
These antitumor potentials were accompanied by the increase in p-AMPK and p-Acc as well as antitumor proteins p53 and p21.
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17403031 Bourguignon LY, Gilad E, Peyrollier K, Brightman A, Swanson RA: Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. J Neurochem. 2007 May;101(4):1002-17. Epub 2007 Mar 30.


To determine the cellular and molecular basis of these events, we focused on PKN gamma, a Rac1-activated serine/threonine kinase in astrocytes.
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