Protein Information

Name lipoprotein lipase
Synonyms LIPD; LPL; LPL protein; Lipase D; Lipoprotein lipase; Lipoprotein lipase precursor; Lipoprotein lipase variant; LPL proteins…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
17725831 Salas A, Noe V, Ciudad CJ, Romero MM, Remesar X, Esteve M: Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue. BMC Genomics. 2007 Aug 28;8:292.


The use of real-time PCR validate that, in mesenteric white adipose tissue, mRNA levels for Lipoprotein Lipase (LPL) were decreased by 52%, those of Fatty Acid Synthase (FAS) by 95%, those of Hormone Sensible Lipase (HSL) by 32%, those of Acetyl CoA Carboxylase (ACC) by 92%, those of Carnitine Palmitoyltransferase 1b (CPT1b) by 45%, and those of Fatty Acid Transport Protein 1 (FATP1) and Adipocyte Fatty Acid Binding Protein (FABP4) by 52% and 49%, respectively.
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19255584 Carmona MC, Amigo M, Barcelo-Batllori S, Julia M, Esteban Y, Moreno S, Gomis R: Dual effects of sodium tungstate on adipocyte biology: inhibition of adipogenesis and stimulation of cellular oxygen consumption. Int J Obes. 2009 May;33(5):534-40. Epub 2009 Mar 3.


Expression of key genes for adipocyte function (aP2, ACC, fatty acid synthase (FAS) and lipoprotein lipase (LPL)) and differentiation (CCAAT enhancer-binding protein (C/EBP) alpha and peroxisome proliferator-activated receptor gamma (PPARgamma)) was reduced by sodium tungstate, whereas C/EBPbeta isoform LIP expression level was increased.
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20205889 Zhao S, Wang J, Song X, Zhang X, Ge C, Gao S: Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue. Nutr Metab. 2010 Jan 21;7:6.


HP promoted gene and protein expression and enzyme activities of lipoprotein lipase (LPL), carmitine palmtoyltransferase-1B (CPT-1B), peroxisome proliferator-activated receptor gamma (PPARgamma) and adipocyte-fatty acid binding proteins (A-FABP) at 60 kg, but reduced their expression at 100 kg.Gene expression and enzyme activity of hormone sensitive lipase (HSL) was reduced markedly at 60 kg but increased at 100 kg by the high dietary protein.
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18975056 Han C, Wang J, Li L, Wang L, Zhang Z: The role of LXR alpha in goose primary hepatocyte lipogenesis. Mol Cell Biochem. 2009 Feb;322(1-2):37-42. Epub 2008 Oct 31.


Triglyceride (TG) accumulation, acetyl-CoA carboxylase alpha (ACC alpha) and fatty acid synthase (FAS) activities, and gene expression levels of LXR alpha, sterol regulatory element-binding proteins-1 (SREBP-1), FAS, ACC alpha and lipoprotein lipase (LPL) were measured in primary hepatocytes.
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20019905 Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS: Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect. 2009 Oct;117(10):1549-55. Epub 2009 Jun 29.


This excess of pWAT was associated with adipocyte hypertrophy and overexpression of lipogenic genes such as C/EBP-alpha (CAAT enhancer binding protein alpha), PPAR-gamma (peroxisome proliferator-activated receptor gamma), SREBP-1C (sterol regulatory element binding protein-1C), LPL (lipoprotein lipase), FAS (fatty acid synthase), and SCD-1 (stearoyl-CoA desaturase 1).
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