| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | 1,3-dichloropropene |
|---|---|
| CAS | 1,3-dichloro-1-propene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10100023 | Secondin L, Maso S, Trevisan A: Different effects of (CIS+TRANS) 1,3-dichloropropene in renal cortical slices derived from male and female rats. Hum Exp Toxicol. 1999 Feb;18(2):106-10. Nephrotoxic effects of 1,3-dichloropropene (cis and trans isomers mixture) was investigated in vitro by means of renal cortical slice model in male and female rats, including treatment with metabolism modifiers as an inducer of cytochrome P-450 1A class (beta-naphthoflavone), a depleting (DL-buthionine-[S,R]-sulfoximine), an inhibitor of gamma-glutamyl-transferase (AT-125) and inhibitor of cysteine conjugate beta-lyase (aminooxiacetic acid). |
81(1,1,1,1) | Details |
| 8511772 | Martelli A, Allavena A, Ghia M, Robbiano L, Brambilla G: Cytotoxic and genotoxic activity of 1,3-dichloropropene in cultured mammalian cells. Toxicol Appl Pharmacol. 1993 May;120(1):114-9. The increase in the frequency of DNA breaks observed in rat hepatocytes after GSH depletion confirms the role of this tripeptide in DCP detoxification; its reduction in hepatocytes simultaneously exposed to is consistent with a cytochrome P450-dependent biotransformation of DCP to more toxic metabolites. |
1(0,0,0,1) | Details |
| 8511773 | Ghia M, Robbiano L, Allavena A, Martelli A, Brambilla G: Genotoxic activity of 1,3-dichloropropene in a battery of in vivo short-term tests. Toxicol Appl Pharmacol. 1993 May;120(1):120-5. A role of cytochrome P450 in the activation of DCP is suggested by the lower degree of liver DNA fragmentation observed in rats pretreated with methoxsalen. |
1(0,0,0,1) | Details |