Protein Information

Name CUL1
Synonyms CUL 1; CUL1; Cullin 1; Cullin 1s

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
12839993 Hellmann H, Hobbie L, Chapman A, Dharmasiri S, Dharmasiri N, del Pozo C, Reinhardt D, Estelle M: Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis. EMBO J. 2003 Jul 1;22(13):3314-25.

5(0,0,0,5) Details
19114460 Gilkerson J, Hu J, Brown J, Jones A, Sun TP, Callis J: Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. Genetics. 2009 Mar;181(3):945-63. Epub 2008 Dec 29.

4(0,0,0,4) Details
15208392 Chuang HW, Zhang W, Gray WM: Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF (TIR1) ubiquitin ligase. Plant Cell. 2004 Jul;16(7):1883-97. Epub 2004 Jun 18.


Previous biochemical studies of CAND1 have suggested that it specifically binds to unmodified CUL1 to negatively regulate SCF assembly.
2(0,0,0,2) Details
18088308 Salmon J, Ramos J, Callis J: Degradation of the auxin response factor ARF1. . Plant J. 2008 Apr;54(1):118-28. Epub 2007 Dec 15.


Aux/IAA family members with domain II sequences are rapidly degraded, show auxin-enhanced degradation rates, and interact with the related F-box proteins TIR1 and AFB1-3, which indicates that they are ubiquitylated by a CUL1-dependent E3 ligase.
1(0,0,0,1) Details