Protein Information

Name cullin
Synonyms Cullin

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
16920877 Walsh TA, Neal R, Merlo AO, Honma M, Hicks GR, Wolff K, Matsumura W, Davies JP: Mutations in an auxin receptor homolog AFB5 and in SGT1b confer resistance to synthetic picolinate auxins and not to 2,4-dichlorophenoxyacetic acid or indole-3-acetic acid in Arabidopsis. Plant Physiol. 2006 Oct;142(2):542-52. Epub 2006 Aug 18.


TIR1 is the recognition component of the Skp1-cullin-F-box complex associated with the ubiquitin-proteasome pathway involved in auxin signaling and has recently been shown to be a receptor for IAA and 2,4-D.
2(0,0,0,2) Details
15208392 Chuang HW, Zhang W, Gray WM: Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF (TIR1) ubiquitin ligase. Plant Cell. 2004 Jul;16(7):1883-97. Epub 2004 Jun 18.

2(0,0,0,2) Details
12226665 Xie Q, Guo HS, Dallman G, Fang S, Weissman AM, Chua NH: SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature. 2002 Sep 12;419(6903):167-70.


The genes AXR1 and TIR1 aid the assembly of an active SCF (Skp1/Cullin/F-box) complex that probably promotes degradation of the AUX/IAA transcriptional repressors in response to auxin.
1(0,0,0,1) Details
14617065 Tian Q, Nagpal P, Reed JW: Regulation of Arabidopsis SHY2/IAA3 protein turnover. Plant J. 2003 Dec;36(5):643-51.

Auxin regulates turnover of the related Auxin-resistant (AXR) 2/IAA7 and AXR3/IAA17 proteins by increasing their interaction with the Skp1-Cdc53/cullin-F-box (SCFTIR1) E3 ubiquitin ligase complex.
Light did not affect the interaction, suggesting that light regulates some other aspect of Aux/IAA gene or protein function.
1(0,0,0,1) Details
15295098 Kepinski S, Leyser O: Auxin-induced SCFTIR1-Aux/IAA interaction involves stable modification of the SCFTIR1 complex. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12381-6. Epub 2004 Aug 4.


SKP1, Cullin, and an F-box-containing protein (SCF)-mediated degradation is an important component of many eukaryotic signaling pathways.
1(0,0,0,1) Details