Protein Information

Name ubiquitin protein ligase
Synonyms E2(25K); Ubiquitin carrier protein; Ubiquitin protein ligase; E2 25K; HIP 2; HIP2; HYPG; Huntingtin interacting protein 2…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
12839993 Hellmann H, Hobbie L, Chapman A, Dharmasiri S, Dharmasiri N, del Pozo C, Reinhardt D, Estelle M: Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis. EMBO J. 2003 Jul 1;22(13):3314-25.


One of the effects of auxin is to stimulate degradation of the Aux/IAA auxin response proteins through the action of the ubiquitin protein ligase SCF (TIR1).
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15546359 Yang X, Lee S, So JH, Dharmasiri S, Dharmasiri N, Ge L, Jensen C, Hangarter R, Hobbie L, Estelle M: The IAA1 protein is encoded by AXR5 and is a substrate of SCF (TIR1). Plant J. 2004 Dec;40(5):772-82.


TIR1 is part of a ubiquitin protein ligase required for degradation of Aux/IAA proteins.
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12226665 Xie Q, Guo HS, Dallman G, Fang S, Weissman AM, Chua NH: SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature. 2002 Sep 12;419(6903):167-70.


Here we show that SINAT5, an Arabidopsis homologue of the RING-finger Drosophila protein SINA, has ubiquitin protein ligase activity and can ubiquitinate NAC1.
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12782725 Gray WM, Muskett PR, Chuang HW, Parker JE: Arabidopsis SGT1b is required for SCF (TIR1)-mediated auxin response. Plant Cell. 2003 Jun;15(6):1310-9.


This complex functions as a ubiquitin protein ligase that targets members of the auxin/indoleacetic acid (Aux/IAA) family of transcriptional regulators for ubiquitin-mediated degradation in response to auxin.
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11709180 Rogg LE, Bartel B: Auxin signaling: derepression through regulated proteolysis. Dev Cell. 2001 Nov;1(5):595-604.


Aux/IAA proteins are unstable, and their degradation is triggered by a ubiquitin-protein ligase that is regulated by modification with a ubiquitin-related protein.
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16488128 Parry G, Estelle M: Auxin receptors: a new role for F-box proteins. Curr Opin Cell Biol. 2006 Apr;18(2):152-6. Epub 2006 Feb 17.


Genetic and biochemical studies have shown that this degradation is dependent on a ubiquitin protein ligase called SCF (TIR1).
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15917797 Dharmasiri N, Dharmasiri S, Estelle M: The F-box protein TIR1 is an auxin receptor. . Nature. 2005 May 26;435(7041):441-5.


Recent studies indicate that auxin acts by promoting the degradation of the Aux/IAA transcriptional repressors through the action of the ubiquitin protein ligase SCF (TIR1).
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