| Name | AP 1 (protein family or complex) |
|---|---|
| Synonyms | AP 1; AP 1 complex; AP1; Adapter related protein complex 1 |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7862446 | Sonobe MH, Yoshida T, Murakami M, Kameda T, Iba H: fra-2 promoter can respond to serum-stimulation through AP-1 complexes. . Oncogene. 1995 Feb 16;10(4):689-96. |
3(0,0,0,3) | Details |
| 11071861 | Ui M, Mizutani T, Takada M, Arai T, Ito T, Murakami M, Koike C, Watanabe T, Yoshimatsu K, Iba H: Endogenous AP-1 levels necessary for oncogenic activity are higher than those sufficient to support normal growth. Biochem Biophys Res Commun. 2000 Nov 11;278(1):97-105. |
3(0,0,0,3) | Details |
| 9500440 | Kameda T, Iba H: Suppression of cellular transformation by glucocorticoid receptor mutants. Cancer Res. 1998 Mar 1;58(5):867-70. Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. |
3(0,0,0,3) | Details |
| 8437852 | Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H: Escape from redox regulation enhances the transforming activity of Fos. Oncogene. 1993 Mar;8(3):695-701. Fos and Jun form dimeric complexes that bind to DNA sequences containing activator protein 1 (AP-1) sites and regulate gene expression. |
3(0,0,0,3) | Details |
| 9149901 | Kameda T, Watanabe H, Iba H: C-Jun and JunD suppress maturation of chondrocytes. . Cell Growth Differ. 1997 May;8(5):495-503. To analyze the function of AP-1 in cartilage formation, two types of primary chondrocytes, LS and US cells, were prepared from caudal (lower) and cephalic (upper) regions of chicken sterna, respectively. |
2(0,0,0,2) | Details |
| 1945831 | Suzuki T, Okuno H, Yoshida T, Endo T, Nishina H, Iba H: Difference in transcriptional regulatory function between c-Fos and Fra-2. . Nucleic Acids Res. 1991 Oct 25;19(20):5537-42. Like c-Fos and Fra-1, Fra-2 formed stable heterodimers with c-Jun, JunB or JunD in vitro and all these complexes had specific DNA-binding activity to AP-1-binding sites (AP-1 sites) or related sequences. |
2(0,0,0,2) | Details |
| 9188858 | Murakami M, Sonobe MH, Ui M, Kabuyama Y, Watanabe H, Wada T, Handa H, Iba H: Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1. Oncogene. 1997 May 22;14(20):2435-44. |
2(0,0,0,2) | Details |
| 11108151 | Matsubara H, Moriguchi Y, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Uchiyama-Tanaka Y, Fujiyama S, Koyama Y, Nose-Fujiyama A, Iba S, Tateishi E, Iwasaka T: Transactivation of EGF receptor induced by angiotensin II regulates fibronectin and TGF-beta gene expression via transcriptional and post-transcriptional mechanisms. Mol Cell Biochem. 2000 Sep;212(1-2):187-201. We isolated the rat fibronectin gene including the 5'-flanking region and found that the AP-1 binding site present in the promoter region was responsible for the Ang II responsiveness of this gene. |
2(0,0,0,2) | Details |
| 1900269 | Suzuki T, Hashimoto Y, Okuno H, Sato H, Nishina H, Iba H: High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts. Jpn J Cancer Res. 1991 Jan;82(1):58-64. Gel shift analysis using nuclear extracts from DS3-infected CEF revealed that the Fra-2/Jun complex contributes to the basal level of AP-1 DNA binding activity. |
2(0,0,0,2) | Details |
| 10359014 | Murakami M, Ui M, Iba H: Fra-2-positive autoregulatory loop triggered by mitogen-activated protein kinase (MAPK) and Fra-2 phosphorylation sites by MAPK. Cell Growth Differ. 1999 May;10(5):333-42. We reported previously that activation of endogenous activator protein 1 (AP-1) in chicken embryo fibroblasts is essential for the cellular transformation induced by v-src, and we further showed that the activation of AP-1 is accompanied by elevation of Fra-2 and c-Jun expression and also high-level phosphorylation of Fra-2 by activated endogenous extracellular signal-regulated kinase [mitogen-activated protein kinase (MAPK)]. |
2(0,0,0,2) | Details |
| 18384814 | Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H: miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008 May 2;378(3):492-504. Epub 2008 Mar 15. We show that activation protein 1 (AP-1) activates the miR-21 transcription in conjugation with the SWI/SNF complex, after PMA stimulation, through the conserved AP-1 and PU.1 binding sites in the promoter identified here. |
2(0,0,0,2) | Details |
| 11566906 | Shibasaki Y, Matsubara H, Nozawa Y, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 phosphatase. Hypertension. 2001 Sep;38(3):367-72. Induction of fibronectin gene containing an AP-1 responsive element in its 5'-flanking region was decreased by 37% after AT (2) stimulation, corresponding to the results of gel mobility assay with the AP-1 sequence of fibronectin as a probe. |
2(0,0,0,2) | Details |
| 8415709 | Kameda T, Akahori A, Sonobe MH, Suzuki T, Endo T, Iba H: JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9369-73. The transcriptional activity of these mutants was analyzed by means of transient expression experiments in F9 cells using a reporter gene containing a single AP-1 binding site. |
1(0,0,0,1) | Details |
| 1923517 | Okuno H, Suzuki T, Yoshida T, Hashimoto Y, Curran T, Iba H: Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene. Oncogene. 1991 Sep;6(9):1491-7. Inhibition of jun transformation was associated with the appearance of supFos1-Jun heterodimers and a reduction in the AP-1 DNA-binding activity contributed by Jun homodimers. |
1(0,0,0,1) | Details |
| 12493776 | Yamamichi-Nishina M, Ito T, Mizutani T, Yamamichi N, Watanabe H, Iba H: SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level. J Biol Chem. 2003 Feb 28;278(9):7422-30. Epub 2002 Dec 17. Run-on analysis indicated that, unlike these four genes driven by AP-1, transcription of the BRG1 and Brm genes in SW13 (vim-) are initiated at a frequency comparable with SW13 (vim+). |
1(0,0,0,1) | Details |
| 11053448 | Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H: Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. J Biol Chem. 2001 Jan 26;276(4):2852-7. Epub 2000 Oct 26. Fos family proteins form stable heterodimers with Jun family proteins, and each heterodimer shows distinctive transactivating potential for regulating cellular growth, differentiation, and development via AP-1 binding sites. |
1(0,0,0,1) | Details |
| 7687344 | Yoshida T, Suzuki T, Sato H, Nishina H, Iba H: Analysis of fra-2 gene expression. Nucleic Acids Res. 1993 Jun 11;21(11):2715-21. Two typical AP-1 sequences are located between the major transcriptional initiation site and the coding sequence, and the binding activity of protein complexes to these sequences was induced by serum. |
1(0,0,0,1) | Details |
| 8189491 | Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H: Analysis of AP-1 function in cellular transformation pathways. J Virol. 1994 Jun;68(6):3527-35. |
4(0,0,0,4) | Details |