Protein Information

Name CA1
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
7500129 Ishibashi H, Akaike N: Somatostatin modulates high-voltage-activated Ca2+ channels in freshly dissociated rat hippocampal neurons. J Neurophysiol. 1995 Sep;74(3):1028-36.

Omega-Conotoxin-GVIA, omega-agatoxin-IVA, nicardipine, and omega-conotoxin-MVIIC blocked HVA IBa by 27, 13, 38, and 9% of the total HVA current, respectively, which suggested the existence of N-, P-, L-, and Q-type HVA Ca2+ channels in the hippocampal CA1 pyramidal neurons.(ABSTRACT TRUNCATED AT 250 WORDS)
32(0,1,1,2) Details
19472050 Kimoto H, Eto R, Abe M, Kato H, Araki T: Alterations of glial cells in the mouse hippocampus during postnatal development. Cell Mol Neurobiol. 2009 Dec;29(8):1181-9. Epub .


We investigated the postnatal alterations of neurons, astrocyte, oligodendrocyte, and microglia in the mouse hippocampal CA1 sector and dentate gyrus under the same conditions using immunohistochemistry.
9(0,0,0,9) Details
16841189 Hwang IK, Yoo KY, Kim DW, Choi SY, Kang TC, Kim YS, Won MH: Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion. Neurochem Res. 2006 Jul;31(7):957-65. Epub 2006 Jul 14.

8(0,0,0,8) Details
19368835 Hwang IK, Yoo KY, Yi SS, Kim IY, Hwang HS, Lee KY, Choi SM, Lee IS, Yoon YS, Kim SY, Won MH, Seong JK: Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils. Brain Res. 2009 Mar 31;1263:134-42. Epub 2009 Jan 31.

6(0,0,0,6) Details
18057827 Choi JH, Lee CH, Hwang IK, Won MH, Seong JK, Yoon YS, Lee HS, Lee IS: Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and protein level in the gerbil hippocampal CA1 region. J Vet Med Sci. 2007 Nov;69(11):1131-6.

6(0,0,0,6) Details
19235887 Hwang IK, Yoo KY, Li H, Park OK, Lee CH, Choi JH, Jeong YG, Lee YL, Kim YM, Kwon YG, Won MH: Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J Neurosci Res. 2009 Jul;87(9):2126-37.


In the present study, we used Mongolian gerbils to investigate IPA's neuroprotective effects against ischemic damage and its antioxidative effects in the hippocampal CA1 region (CA1) after 5 min of transient forebrain ischemia.
3(0,0,0,3) Details
18270819 Hwang IK, Lee CH, Li H, Yoo KY, Choi JH, Kim DW, Kim DW, Suh HW, Won MH: Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs. Neurochem Res. 2008 Jul;33(7):1309-15. Epub 2008 Feb 13.

3(0,0,0,3) Details
9878884 Potier B, Rovira C: Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Brain Res. 1999 Jan 23;816(2):587-97.

Genistein (100 microM) and tyrphostin B42 (100 microM), two PTKs inhibitors, reduced the steady-state barium current (IBa).
2(0,0,0,2) Details
18850268 Hwang IK, Kim IY, Kim YN, Yi SS, Park IS, Min BH, Doo HK, Ahn SY, Kim YS, Lee IS, Yoon YS, Seong JK: Comparative study on high fat diet-induced 4-hydroxy-2E-nonenal adducts in the hippocampal CA1 region of C57BL/6N and C3H/HeN mice. Neurochem Res. 2009 May;34(5):964-72. Epub 2008 Oct 11.

4(0,0,0,4) Details
8981486 Hsu KS, Huang CC, Lyu PC: Inhibition of calcium channels in rat hippocampal CA1 neurons by conantokin-T. Neurosci Lett. 1996 Dec 13;220(2):113-6.

Conantokin-T inhibited the whole-cell Ba2+ current (IBa) in a concentration-dependent manner.
2(0,0,0,2) Details
19122416 Lee CH, Hwang IK, Lee IS, Yoo KY, Choi JH, Lee BH, Won MH: Differential immunoreactivity of microglial and astrocytic marker protein in the hippocampus of the seizure resistant and sensitive gerbils. J Vet Med Sci. 2008 Dec;70(12):1405-9.


The density of Iba-1 immunoreactive microglia in the hippocampal CA1 region (CA1) and dentate gyrus (DG) of the SS gerbil was higher than that in the SR gerbil, and many Iba-1 immunoreactive microglia in the SS gerbil were hypertrophied in morphology.
2(0,0,0,2) Details
20121416 Haselkorn ML, Shellington D, Jackson E, Vagni VA, Janesko KL, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM: Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice. J Neurotrauma. 2010 Feb 1.


A1AR KO mice exhibited enhanced microglial proliferation; specifically, Iba-1+ microglia were increased 20-50% more in A1AR KO vs WT in ipsilateral cortex, CA3, and thalamus, and contralateral cortex, CA1, and thalamus (p <0.05).
1(0,0,0,1) Details
8814609 Pancrazio JJ: Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea-pig myocytes. J Physiol. 1996 Jul 1;494 ( Pt 1):91-103.

Measurement of the current carried by Ba2+ through Ca2+ channels (IBa) permitted the isolation of the slow component of inactivation.
Halothane (0.9 mM in solution) and isoflurane (0.8 mM in solution) decreased peak whole-cell CA2+ current (ICa) by approximately 40 and approximately 20%, respectively, while increasing the apparent rate of inactivation. 4.
1(0,0,0,1) Details
8088342 Ito C, Im WB, Takagi H, Takahashi M, Tsuzuki K, Liou SY, Kunihara M: U-92032, a T-type Ca2+ channel blocker and antioxidant, reduces neuronal ischemic injuries. Eur J Pharmacol. 1994 May 23;257(3):203-10.


U-92032, like flunarizine, blocked transient Ba2+ currents (IBa) through T-type Ca2+ channels with no effect on nifedipine-sensitive non-inactivating currents.
0(0,0,0,0) Details