| Name | transcription factor AP 1 |
|---|---|
| Synonyms | AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun… |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10359014 | Murakami M, Ui M, Iba H: Fra-2-positive autoregulatory loop triggered by mitogen-activated protein kinase (MAPK) and Fra-2 phosphorylation sites by MAPK. Cell Growth Differ. 1999 May;10(5):333-42. We reported previously that activation of endogenous activator protein 1 (AP-1) in chicken embryo fibroblasts is essential for the cellular transformation induced by v-src, and we further showed that the activation of AP-1 is accompanied by elevation of Fra-2 and c-Jun expression and also high-level phosphorylation of Fra-2 by activated endogenous extracellular signal-regulated kinase [mitogen-activated protein kinase (MAPK)]. |
3(0,0,0,3) | Details |
| 8189491 | Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H: Analysis of AP-1 function in cellular transformation pathways. J Virol. 1994 Jun;68(6):3527-35. CEF transformed by v-src, v-yes, v-fps, c-Ha-ras, and N-terminally truncated c-raf were also induced to revert to the normal phenotype by these transdominant mutants, suggesting that functional transcription factor AP-1 activity is essential for the cellular transformation induced by these oncogenes. |
3(0,0,0,3) | Details |
| 9569029 | Matsumoto K, Saitoh K, Koike C, Narita T, Yasugi S, Iba H: Differential expression of fos and jun family members in the developing chicken gastrointestinal tract. Oncogene. 1998 Mar 26;16(12):1611-6. We have analysed the expression patterns of all the known fos/jun family genes, which encode the components of the transcription factor AP-1, in the chicken embryonic digestive tract that develops into the esophagus, proventriculus, gizzard, small intestine, ceca and large intestine. |
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| 10856308 | Murasawa S, Matsubara H, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Kitabayashi I, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Iba S, Iwasaka T: Angiotensin II initiates kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. J Biol Chem. 2000 Sep 1;275(35):26856-63. |
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| 1900269 | Suzuki T, Hashimoto Y, Okuno H, Sato H, Nishina H, Iba H: High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts. Jpn J Cancer Res. 1991 Jan;82(1):58-64. |
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| 11302725 | Matsubara H, Shibasaki Y, Okigaki M, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Effect of angiotensin II type 2 receptor on kinase Pyk2 and c-Jun NH2-terminal kinase via SHP-1 phosphatase activity: evidence from vascular-targeted transgenic mice of AT2 receptor. Biochem Biophys Res Commun. 2001 Apr 20;282(5):1085-91. |
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| 9500440 | Kameda T, Iba H: Suppression of cellular transformation by glucocorticoid receptor mutants. Cancer Res. 1998 Mar 1;58(5):867-70. Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. |
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| 9662434 | Ui M, Sonobe MH, Ito T, Murakami M, Okazaki S, Takada M, Sato T, Iba H: Biochemical and functional analysis of highly phosphorylated forms of c-Jun protein. FEBS Lett. 1998 Jun 16;429(3):289-94. |
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| 9188858 | Murakami M, Sonobe MH, Ui M, Kabuyama Y, Watanabe H, Wada T, Handa H, Iba H: Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1. Oncogene. 1997 May 22;14(20):2435-44. The major changes in the expression levels of fos and jun family genes induced by v-src were the elevation of fra-2 and c-jun transcripts. |
1(0,0,0,1) | Details |
| 11108151 | Matsubara H, Moriguchi Y, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Uchiyama-Tanaka Y, Fujiyama S, Koyama Y, Nose-Fujiyama A, Iba S, Tateishi E, Iwasaka T: Transactivation of EGF receptor induced by angiotensin II regulates fibronectin and TGF-beta gene expression via transcriptional and post-transcriptional mechanisms. Mol Cell Biochem. 2000 Sep;212(1-2):187-201. We concluded that Ang II-induced expression of fibronectin and TGF-beta is mediated by downstream signaling of EGF-R transactivated by Ca2+-dependent kinase, and that Ang II-induced fibronectin mRNA expression is regulated by two different mechanisms; transcriptional control by binding of c-fos/c-jun complex to the AP-1 site, and post-transcriptional control by mRNA stabilization due to autocrine and/or paracrine effects of TGF-beta. |
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| 7936655 | Foletta VC, Sonobe MH, Suzuki T, Endo T, Iba H, Cohen DR: Cloning and characterisation of the mouse fra-2 gene. Oncogene. 1994 Nov;9(11):3305-11. Transcription factor AP-1 is comprised of multiple protein complexes that include members of a family of genes related to the proto-oncogene c-fos. |
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| 2514403 | Yoshida T, Shindo Y, Ohta K, Iba H: Identification of a small region of the v-fos gene product that is sufficient for transforming potential and growth-stimulating activity. Oncogene Res. 1989;5(2):79-89. Additionally, this sequence shares some homology with the DNA binding domain of GCN4 and c-jun protein. |
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| 9753632 | Okazaki S, Ito T, Ui M, Watanabe T, Yoshimatsu K, Iba H: Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator. Biochem Biophys Res Commun. 1998 Sep 18;250(2):347-53. The junD gene encodes one component of the transcription factor, AP-1. |
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| 2110368 | Nishina H, Sato H, Suzuki T, Sato M, Iba H: Isolation and characterization of fra-2, an additional member of the fos gene family. Proc Natl Acad Sci U S A. 1990 May;87(9):3619-23. The fra-2 gene product formed a complex in cells with the c-Jun protein, indicating that c-fos and fra-2 share biological and biochemical functions. |
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| 1923517 | Okuno H, Suzuki T, Yoshida T, Hashimoto Y, Curran T, Iba H: Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene. Oncogene. 1991 Sep;6(9):1491-7. The protein products of the fos and jun oncogenes (Fos and Jun) function as transcriptional regulators in the form of homo- or heterodimeric complexes that bind to DNA. |
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| 12493776 | Yamamichi-Nishina M, Ito T, Mizutani T, Yamamichi N, Watanabe H, Iba H: SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level. J Biol Chem. 2003 Feb 28;278(9):7422-30. Epub 2002 Dec 17. The presence of BRG1 and Brm in SW13 correlates completely with the cellular ability to express such genes as vimentin, collagenase, c-met, and CD44 that were under the control of a transcription factor, AP-1, which was shown previously to require a functional SWI/SNF complex for its transactivating activity. |
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| 8437852 | Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H: Escape from redox regulation enhances the transforming activity of Fos. Oncogene. 1993 Mar;8(3):695-701. Fos and Jun form dimeric complexes that bind to DNA sequences containing activator protein 1 (AP-1) sites and regulate gene expression. |
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| 11053448 | Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H: Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. J Biol Chem. 2001 Jan 26;276(4):2852-7. Epub 2000 Oct 26. BAF60a binds to a specific subset of Fos/Jun heterodimers using two different interfaces for c-Fos and c-Jun, respectively. |
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| 9149901 | Kameda T, Watanabe H, Iba H: C-Jun and JunD suppress maturation of chondrocytes. . Cell Growth Differ. 1997 May;8(5):495-503. |
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| 7862446 | Sonobe MH, Yoshida T, Murakami M, Kameda T, Iba H: fra-2 promoter can respond to serum-stimulation through AP-1 complexes. . Oncogene. 1995 Feb 16;10(4):689-96. In growth-arrested CEF, small amounts of Fra-2/c-Jun complex bind to the AP-1 consensus sequences in fra-2 promoter, while a significant part of the enhanced AP-1 binding activity after 60-120 min of serum stimulation is attributable to c-Fos/c-Jun heterodimer. |
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| 1945831 | Suzuki T, Okuno H, Yoshida T, Endo T, Nishina H, Iba H: Difference in transcriptional regulatory function between c-Fos and Fra-2. . Nucleic Acids Res. 1991 Oct 25;19(20):5537-42. Like c-Fos and Fra-1, Fra-2 formed stable heterodimers with c-Jun, JunB or JunD in vitro and all these complexes had specific DNA-binding activity to AP-1-binding sites (AP-1 sites) or related sequences. |
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